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NMNAT3, human recombinant

Catalyzes the formation of NAD+ from nicotinamide mononucleotide (NMN) and ATP.
Catalog #: 7562

In stock

SKU-Size Size Price Qty
7562-10 10 μg
$250.00
7562-50 50 μg
$815.00
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Product Details

Alternate Name Nicotinamide Mononucleotide Adenylyl-transferase 3; NMN Adenylyltransferase 3; NaMN Adenylyltransferase 3; EC 2.7.7.18; EC 2.7.7.1
Gene Symbol NMNAT3
Gene ID 349565
Accession # Q96T66
Source E. coli
Appearance Liquid
Physical Form Description 1 mg/ml in 50 mM sodium phosphate, pH 8.0 containing 300 mM sodium chloride, 1 mM DTT and 10% glycerol.
Molecular Weight ~27.0 kDa (monomer). Human full-length NMNAT3 (aa 1-252) is fused at the N-terminus to a His-tag.
Purity by SDS-PAGE ≥95%
Biological Activity ≥ 2U/mg protein. One unit is defined as the amount of enzyme that synthesizes 1 µmol of NAD+ per min.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

This is the Mitochondrial NMNAT isoform. It catalyzes the formation of NAD+ from nicotinamide mononucleotide (NMN) and ATP. It can also use the deamidated form of nicotinic acid mononucleotide (NAMN) as substrate with the same efficiency. It can use tiazofurin monophosphate as substrate. It can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD+. For the pyrophosphorolytic activity, mitochondrial NMNAT isoform can use NAD (+), NADH, NAAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. It fails to cleave phosphorylated dinucleotides NADP+, NADPH and NAADP+. It protects against axonal degeneration following injury.


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