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NLRP3i

A NLRP3 inflammasome inhibitor
Catalog #: B2529
SKU-Size Size Price Qty
B2529-10 10 mg
$115.00
B2529-50 50 mg
$395.00
More Sizes Get Quote

Product Details

Alternate Name JC121, N-[2-[4-(Aminosulfonyl)phenyl]ethyl]-5-chloro-2-methoxybenzamide
Peptide Sequence N/A
Appearance White solid
CAS # 16673-34-0
Molecular Formula C₁₆H₁₇ClN₂O₄S
Molecular Weight 368.84
Purity ≥95%
Solubility >18 mg/ml in DMSO
SMILES COC1=C(C=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)N
InChi InChI=1S/C16H17ClN2O4S/c1-23-15-7-4-12(17)10-14(15)16(20)19-9-8-11-2-5-13(6-3-11)24(18,21)22/h2-7,10H,8-9H2,1H3,(H,19,20)(H2,18,21,22)
InChi Key KVWWTCSJLGHLRM-UHFFFAOYSA-N
PubChem CID 85542
MDL Number MFCD00193756
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

NLRP3i is an intermediate in the glyburide synthesis that acts as a NLRP3 inflammasome inhibitor. It inhibits the formation of the NLRP3 inflammasome in cardiomyocytes and limits the infarct size after myocardial ischemia-reperfusion in the mouse, without affecting glucose metabolism.


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