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based on 3 citations in multiple journalsNimbolide34.1 4
An anticancer agent
Catalog #: 1891
SKU-Size Size Price Qty
1891-5 5 mg
1891-25 25 mg
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Product Details

Alternate Name (4α,5α,6α,7α,15β,17α)-7,15:21,23-Diepoxy-6-hydroxy-4,8-dimethyl-1-oxo-18,24-dinor-11,12-secochola-2,13,20,22-tetraene-4,11-dicarboxylic Αcid γ-lactone Methyl Ester; CCRIS 5723, NSC-309909
Appearance White to off-white solid
CAS # 25990-37-8
Molecular Formula C₂₇H₃₀O₇
Molecular Weight 466.52
Purity ≥98% by TLC
Solubility DMSO (~50 mM) or Ethanol (~ 8 mM)
InChi InChI=1S/C27H30O7/c1-13-15(14-7-9-32-12-14)10-16-20(13)27(4)17(11-19(29)31-5)26(3)18(28)6-8-25(2)22(26)21(23(27)33-16)34-24(25)30/h6-9,12,15-17,21-23H,10-11H2,1-5H3
PubChem CID 100017
MDL Number MFCD01735386
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A terpenoid lactone derived from Azadirachta indica (Neem tree) that displays a variety of biological activities including anti-malarial and anticancer activity. Recently it has also been shown that nimbolide sensitizes colon cancer cells to TRAIL-induced apoptosis through three distinct mechanisms: reactive oxygen species and ERK-mediated up-regulation of DR5 and DR4, downregulation of cell survival proteins, and up-regulation of pro-apoptotic proteins p53 and Bax.

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Chitta et al., Nimbolide targets BCL2 and induces apoptosis in preclinical models of Waldenströms macroglobulinemia. Blood Cancer Journal (2014) 4, e260; doi:10.1038/bcj.2014.74.
Guswanto et al., Evaluation of a Fluorescence-Based Method for Antibabesial Drug Screening. Antimicrob. Agents Chemother., Aug 2014; 58: 4713 - 4717.
Wu et al., Preclinical Evaluation of the Supercritical Extract of Azadirachta Indica(Neem) Leaves In Vitro and In Vivo on Inhibition of Prostate Cancer Tumor Growth. Mol. Cancer Ther., May 2014; 13: 1067 - 1077.
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