Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

Nimbolide

based on 3 citations in multiple journalsNimbolide34.1 4
An anticancer agent
Catalog #: 1891
SKU-Size Size Price Qty
1891-5 5 mg
$215.00
1891-25 25 mg
$875.00
More Sizes Get Quote

Product Details

Alternate Name (4α,5α,6α,7α,15β,17α)-7,15:21,23-Diepoxy-6-hydroxy-4,8-dimethyl-1-oxo-18,24-dinor-11,12-secochola-2,13,20,22-tetraene-4,11-dicarboxylic Αcid γ-lactone Methyl Ester; CCRIS 5723, NSC-309909
Appearance White to off-white solid
CAS # 25990-37-8
Molecular Formula C₂₇H₃₀O₇
Molecular Weight 466.52
Purity ≥98% by TLC
Solubility DMSO (~50 mM) or Ethanol (~ 8 mM)
SMILES CC1=C2C(CC1C3=COC=C3)OC4C2(C(C5(C6C4OC(=O)C6(C=CC5=O)C)C)CC(=O)OC)C
InChi InChI=1S/C27H30O7/c1-13-15(14-7-9-32-12-14)10-16-20(13)27(4)17(11-19(29)31-5)26(3)18(28)6-8-25(2)22(26)21(23(27)33-16)34-24(25)30/h6-9,12,15-17,21-23H,10-11H2,1-5H3
InChi Key JZIQWNPPBKFOPT-UHFFFAOYSA-N
PubChem CID 100017
MDL Number MFCD01735386
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A terpenoid lactone derived from Azadirachta indica (Neem tree) that displays a variety of biological activities including anti-malarial and anticancer activity. Recently it has also been shown that nimbolide sensitizes colon cancer cells to TRAIL-induced apoptosis through three distinct mechanisms: reactive oxygen species and ERK-mediated up-regulation of DR5 and DR4, downregulation of cell survival proteins, and up-regulation of pro-apoptotic proteins p53 and Bax.


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.
Chitta et al., Nimbolide targets BCL2 and induces apoptosis in preclinical models of Waldenströms macroglobulinemia. Blood Cancer Journal (2014) 4, e260; doi:10.1038/bcj.2014.74.
Guswanto et al., Evaluation of a Fluorescence-Based Method for Antibabesial Drug Screening. Antimicrob. Agents Chemother., Aug 2014; 58: 4713 - 4717.
Wu et al., Preclinical Evaluation of the Supercritical Extract of Azadirachta Indica(Neem) Leaves In Vitro and In Vivo on Inhibition of Prostate Cancer Tumor Growth. Mol. Cancer Ther., May 2014; 13: 1067 - 1077.
For more citations of this product click here