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An agonist of FXR
Catalog #: B3029
SKU-Size Size Price Qty
B3029-1 1 mg
B3029-5 5 mg
More Sizes Get Quote

Product Details

Alternate Name LMB 763; 4-[[benzyl-(8-chloro-1-methyl-4H-chromeno[4,3-c]pyrazole-3-carbonyl)amino]methyl]benzoic acid; 4-((N-benzyl-8-chloro-1-methyl-1,4-dihydrochromeno[4,3-c]pyrazole-3-carboxamido)methyl)benzoic acid; Benzoic acid, 4-((((8-chloro-1,4-dihydro-1-methyl(1)benzopyrano(4,3-C)pyrazol-3-yl)carbonyl)(phenylmethyl)amino)methyl)-
Appearance White Solid
CAS # 1773489-72-7
Molecular Formula C₂₇H₂₂ClN₃O₄
Molecular Weight 487.93
Purity ≥98%
Solubility ~83 mg/ml in DMSO (may need ultrasonication)
InChi InChI=1S/C27H22ClN3O4/c1-30-25-21-13-20(28)11-12-23(21)35-16-22(25)24(29-30)26(32)31(14-17-5-3-2-4-6-17)15-18-7-9-19(10-8-18)27(33)34/h2-13H,14-16H2,1H3,(H,33,34)
PubChem CID 118063735
MDL Number MFCD31657267
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Nidufexor is an agonist of Farnesoid X receptor (FXR). Administration of Nidufexor (10 and 30 mg/kg for 3 weeks) modulates FXR-dependent genes in vivo leading to the reduction of steatosis, inflammation, and fibrosis in a murine NASH model. It is in clinical trials in patients with nonalcoholic steatohepatitis (NASH) and diabetic nephropathy.

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