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Nicotinamide N-Methyltransferase, Human Recombinant (hNNMT)

A cytosolic methyltransferase catalyzing the N-methylation of nicotinamide
Catalog #: 7261
SKU-Size Size Price Qty
7261-20 20 μg
$195.00
7261-100 100 μg
$495.00
7261-1000 1 mg
$2,950.00
More Sizes Get Quote

Product Details

Alternate Name NNMT
Gene Symbol NNMT
Gene ID 4837
Accession # P40261
Source E. coli
Appearance Liquid
Physical Form Description 3.42 mg/ml solution in 25 mM Tris (pH8.0) buffer containing 20% glycerol
Molecular Weight 31.7 kDa (263aa + NT 6xHis-tag)
Purity by SDS-PAGE ≥98%
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans

Details

N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. NNMT is an important cytosolic methyltransferase catalyzing the N-methylation of nicotinamide, pyridines and structural analogs, playing a crucial role in the biotransformation and detoxification of many xenobiotic compounds. In the N-methylation process, NNMT uses S-adenosyl methionine as the methyl donor and nicotinamide as methyl acceptor. NNMT is mostly expressed in the liver, and a lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. It may also play an important role in regulating biological processes related to N-methyl nicotinamide such as anti-inflammatory, anti-thrombotic, vasoprotective, and gastroprotective properties. Increased NNMT activity was reported in many kinds of tumors. NNMT is a potential biomarker and therapeutic target in caner diagnosis and treatment. NNMT serum levels have significance in the premature detection and in the management of patients with colorectal cancer. The recombinant protein includes hNNMT with N-terminal His-tag.


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