Product Details
| Alternate Name | 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide |
|---|---|
| Appearance | Off-white to pale yellow solid |
| CAS # | 50-65-7 |
| Molecular Formula | C₁₃H₈Cl₂N₂O₄ |
| Molecular Weight | 327.12 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (10 mM) or Ethanol (25 mM) |
| SMILES | C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O |
| InChi | InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19) |
| InChi Key | RJMUSRYZPJIFPJ-UHFFFAOYSA-N |
| PubChem CID | 4477 |
| MDL Number | MFCD00057597 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
A STAT3 signaling pathway inhibitor. Niclosamide potently inhibits the activation and transcriptional function of STAT3 and induces cell growth inhibition, apoptosis, and cell cycle arrest of cancer cells with constitutively active STAT3. Also reversibly inhibits mTORC1 signaling and stimulates autophagy in vitro; displays antineoplastic effects in acute myelogenous leukemia (AML) stem cells. It is identified in drug screening studies to inhibit SARS-CoV in vitro, presumably by interfering with host-regulated pathways.
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Zhao, Juan et al. (2016) Niclosamide suppresses renal cell carcinoma by inhibiting Wnt/β-catenin and inducing mitochondrial dysfunctions, Springerplus. 2016 Aug 30;5(1):1436.
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