Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

Niclosamide

A STAT3 signaling pathway inhibitor
Catalog #: 1826
SKU-Size Size Price Qty
1826-100 100 mg
$80.00
1826-500 500 mg
$275.00
More Sizes Get Quote

Product Details

Alternate Name 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
Appearance Off-white to pale yellow solid
CAS # 50-65-7
Molecular Formula C₁₃H₈Cl₂N₂O₄
Molecular Weight 327.12
Purity ≥98% by HPLC
Solubility DMSO (10 mM) or Ethanol (25 mM)
SMILES C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O
InChi InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
InChi Key RJMUSRYZPJIFPJ-UHFFFAOYSA-N
PubChem CID 4477
MDL Number MFCD00057597
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A STAT3 signaling pathway inhibitor. Niclosamide potently inhibits the activation and transcriptional function of STAT3 and induces cell growth inhibition, apoptosis, and cell cycle arrest of cancer cells with constitutively active STAT3. Also reversibly inhibits mTORC1 signaling and stimulates autophagy in vitro; displays antineoplastic effects in acute myelogenous leukemia (AML) stem cells. It is identified in drug screening studies to inhibit SARS-CoV in vitro, presumably by interfering with host-regulated pathways.


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.
Zhao, Juan et al. (2016) Niclosamide suppresses renal cell carcinoma by inhibiting Wnt/β-catenin and inducing mitochondrial dysfunctions, Springerplus. 2016 Aug 30;5(1):1436.
For more citations of this product click here