A STAT3 signaling pathway inhibitor
Catalog #: 1826 | abID:

Product Details

Alternate Name 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
Appearance Off-white to pale yellow solid
CAS # 50-65-7
Molecular Formula C₁₃H₈Cl₂N₂O₄
Molecular Weight 327.12
Purity ≥98% by HPLC
Solubility DMSO (10 mM) or Ethanol (25 mM)
SMILES C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O
InChi InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
PubChem CID 4477
MDL Number MFCD00057597
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A STAT3 signaling pathway inhibitor. Niclosamide potently inhibits the activation and transcriptional function of STAT3 and induces cell growth inhibition, apoptosis, and cell cycle arrest of cancer cells with constitutively active STAT3. Also reversibly inhibits mTORC1 signaling and stimulates autophagy in vitro; displays antineoplastic effects in acute myelogenous leukemia (AML) stem cells. It is identified in drug screening studies to inhibit SARS-CoV in vitro, presumably by interfering with host-regulated pathways.

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Zhao, Juan et al. (2016) Niclosamide suppresses renal cell carcinoma by inhibiting Wnt/β-catenin and inducing mitochondrial dysfunctions, Springerplus. 2016 Aug 30;5(1):1436.
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