Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

NI-57

An inhibitor of the bromodomains of BRPF proteins
Catalog #: B2854
SKU-Size Size Price Qty
B2854-1 1 mg
$55.00
B2854-5 5 mg
$175.00
More Sizes Get Quote

Product Details

Alternate Name 4-cyano-N-(1,3-dimethyl-2-oxoquinolin-6-yl)-2-methoxybenzenesulfonamide; 4-cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)-2-methoxy-benzenesulfonamide; 4-Cyano-~{n}-(1,3-Dimethyl-2-Oxidanylidene-Quinolin-6-Yl)-2-Methoxy-Benzenesulfonamide
Appearance A crystalline solid
CAS # 1883548-89-7
Molecular Formula C₁₉H₁₇N₃O₄S
Molecular Weight 383.42
Purity ≥98%
Solubility ~30 mg/ml in DMF
~25 mg/ml in DMSO
SMILES CC1=CC2=C(C=CC(=C2)NS(=O)(=O)C3=C(C=C(C=C3)C#N)OC)N(C1=O)C
InChi InChI=1S/C19H17N3O4S/c1-12-8-14-10-15(5-6-16(14)22(2)19(12)23)21-27(24,25)18-7-4-13(11-20)9-17(18)26-3/h4-10,21H,1-3H3
InChi Key UEMQPCYDWCSVCU-UHFFFAOYSA-N
PubChem CID 91827373
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

NI-57 is an inhibitor of the bromodomains of BRPF proteins. The bromodomain and plant homeodomain finger-containing (BRPF) family are scaffolding proteins important for the recruitment and activation of MOZ/MORF histone acetyltransferases to chromatin. NI-57 binds to BRPF1B, BRPF2 and BRPF3 with Kd values of 31 nM, 108 nM and 408 nM respectively. It inhibits BRPF1 with an IC₅₀ of 114 nM. It shows functional activity in cellular assays by modulating the phenotype at low micromolar concentrations in cancer and inflammatory models.


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.