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NH125

Antibacterial agent, inhibitor of histidine protein kinase and eEF-2 kinase
Catalog #: B2909
SKU-Size Size Price Qty
B2909-1 1 mg
$70.00
B2909-5 5 mg
$280.00
More Sizes Get Quote

Product Details

Alternate Name 1-benzyl-3-hexadecyl-2-methylimidazol-1-ium,iodide; 1-Benzyl-3-Cetyl-2-Methylimidazolium Iodide; eEF-2 Kinase Inhibitor; 1-Hexadecyl-2-methyl-3-(phenylmethyl)-1H-imidazolium iodide
Appearance A crystalline solid
CAS # 278603-08-0
Molecular Formula C₂₇H₄₅IN₂
Molecular Weight 524.56
Purity ≥95%
Solubility ~5 mg/ml in Ethanol
~15 mg/ml in DMF
~2.5 mg/ml in DMSO
SMILES CCCCCCCCCCCCCCCCN1C=C[N+](=C1C)CC2=CC=CC=C2.[I-]
InChi InChI=1S/C27H45N2.HI/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-19-22-28-23-24-29(26(28)2)25-27-20-17-16-18-21-27;/h16-18,20-21,23-24H,3-15,19,22,25H2,1-2H3;1H/q+1;/p-1
InChi Key RVWOHCBHAGBLLT-UHFFFAOYSA-M
PubChem CID 10436839
MDL Number MFCD07370143
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

NH125 is an imidazole that has potent antibacterial properties in drug-resistant bacteria. It inhibits histidine protein kinase YycG with an IC₅₀ of 6.6 µM. It selectively inhibits eEF-2 kinase activity with an IC₅₀ of 60 nM in vitro and weakly inhibits PKC, PKA and CaMK II. It also decreases the viability of several cancer cell lines with IC₅₀ values ranging from 0.7-4.7 µM.


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