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NFkB p65 Antibody

based on 3 citations in multiple journalsNFkB p65 Antibody34.1 4
Catalog #: 3038
SKU-Size Size Price Qty
3038-30T 30 µg
$89.00
3038-100 100 µg
$245.00
More Sizes Get Quote

Product Details

Antibody Target NFkB p65
Alternate Name RELA, NFKB3, MGC131774
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide surrounding amino acid 274 of mouse NFkB p65
Accession # NP_033071
Gene ID 19697
Appearance Colorless liquid
Concentration 0.2 mg/ml
Formulation 100 µg (0.2 mg/ml) affinity purified rabbit anti-NFkB polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 25% glycerol, 0.5% BSA, 0.01% thimerosal.
Purification Affinity purified
Species Reactivity Human, mouse, rat
Application Western blot, Immunohistochemistry
Application & Usage Western blotting (0.5-4 µg/ml), immunocytochemistry (10-20µg/ml). However, the optimal conditions should be determined individually. The antibody detects primarily NFkB p65 in samples of human, mouse, and rat origins.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

NFkB is a heterodimer that consists of a 50 kDa DNA binding subunit (p50) and a 65 kDa transactivation subunit (p65/RelA). Both of these subunits exhibit sequence homology to the protooncogene c-Rel. The p50 has an isoform called p49/p52, and both proteins are derived from the amino-terminal of precursor protein p105 and p100. The p50/p65 heterodimer remains in the cytosol in an inactive form as a complex with its inhibitor, IkB. Upon stimulation of cells by a wide variety of stimuli such as lipopolysaccharide (LPS), pro-inflammatory cytokines (IL-1 & TNF, etc.), and viral infection, IkB is phosphorylated and degraded by proteosome. The active NFkB heterodimer is translocated into the nucleus and induces gene expression.


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Kao, Yu-Han et al. (2015) Regulation of P-glycoprotein expression in brain capillaries in Huntington’s disease and its impact on brain availability of antipsychotic agents risperidone and paliperidone J Cereb Blood Flow Metab. 2016 Aug;36(8):1412-23.
Diwaker et al., Effect of modulation of unfolded protein response pathway on dengue virus infection.  Acta Biochim Biophys Sin, Oct 2015; 10.1093/abbs/gmv108.
Kao et al., Regulation of P-glycoprotein expression in brain capillaries in Huntington's disease and its impact on brain availability of antipsychotic agents risperidone and paliperidone.  Journal of Cerebral Blood Flow and Metabolism, Oct 2015; 10.1177/0271678X15606459.
Rashi-Elkeles et al., Parallel Profiling of the Transcriptome, Cistrome, and Epigenome in the Cellular Response to Ionizing Radiation. Sci. Signal., May 2014; 7: rs3.
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