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NF-κB Inhibitor, SN50

A NF-κB Inhibitor
Catalog #: 2506
SKU-Size Size Price Qty
2506-500 500 µg
$135.00
2506-1000 1 mg
$235.00
More Sizes Get Quote

Product Details

Alternate Name SN50; AAVALLPAVLLALLAPVQRKRQKLMP
Appearance Lyophilized solid
CAS # 213546-53-3
Molecular Formula C₁₂₉H₂₃₀N₃₆O₂₉S
Molecular Weight 2781.5
Purity ≥97% by HPLC
Solubility H₂O
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

This peptide contains the nuclear localization sequence (NLS residues 360-369) of the transcription factor NF-κB p50 linked to a peptide cell-permeablization sequence, the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF). SN50 inhibits translocation of the NF-κB active complex into the nucleus. In mouse endothelial LE-II cells induced with LPS, inhibition of NF-κB nuclear translocation was 88% at 50 µg/ml (18 µM). In human monocytic THP-1 cells induced by LPS or TNFα there was 85% inhibition at 100 µg/ml.


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