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Total D-Amino Acid Assay Kit (K445-100)

June 2018

Total D-Amino Acid Assay Kit (K445-100)


MILPITAS, Calif. - June 21, 2018 - PRLog -- D-Amino acids are present in both eukaryotes and prokaryotes. D-Amino acids act as a component of the cell wall in prokaryotes and a neurological regulator in eukaryotes. In mammals, D-Amino acids play an important role in physiological functions and their levels are regulated by D-Amino acid oxidase in the central nervous systems. Some important D-Amino acids include D-serine, D-aspartate and D-alanine. D-serine acts as a modulator of N-Methyl-D-aspartate receptor (NMDA receptor, NMDAR), while D-aspartate and D-alanine have been found to be elevated in the white and the gray matter respectively in patients' brains suffering Alzheimer's disease. The abnormal levels of D-Amino acids could be used as a marker of neurological diseases: total D-Amino acid concentration in cerebrospinal fluid (CSF) has been shown to be higher in patients with Alzheimer's disease when compared to samples from healthy donors. BioVision's Total D-Amino Acid Assay Kit (Fluorometric) provides a quick, specific and easy method for measuring total D-Amino acid concentrations in a wide variety of samples. In this assay, D-Amino acids are converted into an intermediate by the DAA enzyme mix that will further react with a probe to produce a strong fluorescence signal (Ex/Em= 535/587nm). The kit is simple to use, sensitive and high-throughput adaptable and can detect as low as 1.9 μM of D-Amino acids in biological samples.

Figure:Estimations of total D-Amino acids in rat brain sample and pooled normal human CSF (15 µl) using BioVision K445-100. D-Amino acid concentrations were 15.4 pmol/µg-protein in rat brain and 4.2 µM in Human CSF. Assays were performed following the kit protocol.

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About BioVision:
BioVision, Inc. is a privately held Life Science company headquartered in the beautiful San Francisco Bay area. BioVision develops and offers a wide variety of products including assay kits, antibodies, recombinant proteins & enzymes, and other innovative research tools for studying Apoptosis, Metabolism, Cell Proliferation, Cellular Stress, Cell Damage and Repair, Diabetes, Obesity and Metabolic Syndrome, Stem Cell Biology, Gene Regulation, Signal Transduction, and more.

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