Researchers target previously “undruggable” enzyme to treat Duchenne muscular dystrophy in cells
September 2020  |  Science News
The team of researchers tested their compound in muscle cells and found that it successfully inhibited MKP5 activity, suggesting a promising new therapeutic strategy for treating Duchenne muscular dystrophy (DMD).
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Brain Astrocytes Show Metabolic Alterations in Parkinson’s Disease
September 2020  |  Science News
The researchers found out that astrocytes from PD patients produced significantly higher levels of α-synuclein, a protein that accumulates in PD patients’ brain. One of the key pathological features caused by α-synuclein aggregation is the disruption of calcium homeostasis, and the study showed increased calcium levels in PD astrocytes.
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Polygenic Risk Score Predicts Drug-Induced Liver Injury
September 2020  |  Science News
Scientists have devised a polygenic risk score (PRS) that shows when a drug, whether developmental or already approved—poses a risk of drug-induced liver injury (DILI).
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Fixing Stem Cell Therapy for Heart Repair
September 2020  |  Science News
Study revealed that mouse and human Bone marrow-derived cells (BMCs) do not recover at the same rate and that the impaired healing of post-heart attack BMCs is likely due to inflammation.
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Coaxing single stem cells into specialized cells
September 2020  |  Science News
Researchers have developed a unique method for precisely controlling the deposition of hydrogel, which is made of water-soluble polymers commonly used to support cells in experiments or for therapeutic purposes. Hydrogel mimics the extracellular matrix the natural environment of cells in the body.
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Alzheimer’s Immune Response Interactions Revealed
September 2020  |  Science News
Studies suggests that beta-amyloid has antiviral and antimicrobial properties, offering a potential link between the immune response against infections and the development of Alzheimer’s disease.
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Finding order in the chaos of cancer mutations
September 2020  |  Science News
Researchers have identified that there is an element of order to the seemingly chaotic changes to chromosomes that give tumors their heterogeneity.
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Pancreatic Islet Transplantation May Be Extended by Microgel Delivery Method
September 2020  |  Science News
Scientist implement a synthetic biomaterial platform for the local delivery of a chimeric streptavidin/programmed cell death-1 (SA-PD-L1) protein to direct “reprogramming” of local immune responses to transplanted pancreatic islets.
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Small molecule compound that can activate the Wnt pathway
August 2020  |  Science News
Research has identified a small molecule compound that can activate the Wnt pathway in non-Wnt subtypes of medulloblastoma, making these aggressive forms of cancer more responsive to therapies.
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Reawakening Heart Cells’ Healing System By Targeting Non-Coding RNA in Cellular Models
August 2020  |  Science News
Scientist show that by targeting an essential biomolecule that surges in failing heart muscle, it may be possible to heal damaged heart tissue with medication.
Read the Full Article from TechnologyNetworks