Novel therapy makes oxidative stress deadly to cancer
June 2018 | Science News
Oxidative stress can help tumors thrive, but one way novel cancer treatments work is by pushing levels to the point where it instead helps them die, scientists report.
Study sheds light on the early stages of tumorigenesis
June 2018 | Science News
Researchers from Osaka University have discovered how precancerous cells spread to normal tissue and cause cancer, which could help scientists understand the initial stages of tumor progression.
Aggressive Brain Cancer Can Be Driven by Tumor Suppressor
June 2018 | Science News
AMP-activated protein kinase (AMPK) is involved in regulating cell metabolism and is largely thought to play a suppressive role in cancer. Research by scientists at the Cincinnati Children’s Cancer and Blood Diseases Institute has now indicated that the protein may represent a key driver of aggressive brain cancers, including glioblastoma (GBM).
Gene editing technology predicts heart disease risk
June 2018 | Science News
Scientists may now be able to use gene editing and stem cell technologies to predict whether carrying a specific gene variant increases a person’s risk of heart disease, according to a new study published in the American Heart Association's journal Circulation.
Aggressive Lymphoma Linked with JAK Inhibitor Use
June 2018 | Science News
One of three disorders that fall under the umbrella of myeloproliferative neoplasms is myelofibrosis, which can lead to scarring and hardening inside the bone marrow. The exact cause of myelofibrosis is not known, but it has been linked to the JAK2 gene, which controls the production of blood cells. Doctors often treat the condition with the JAK1/2 inhibitor ruxolitinib.
Exosomes Shown to Be Involved in Spread of Amyloid Beta in Alzheimer’s
June 2018 | Science News
Researchers report that exosomes appear to play a key role in the spread of Alzheimer's disease in the brain. Long understood that the main task of exosomes was to help the cell get rid of waste products, it’s now known that exosomes can contain both proteins and genetic material, which other cells can absorb, explain the scientists.
Dementia can be caused by hypertension
June 2018 | Science News
A new study indicates that patients with high blood pressure are at a higher risk of developing dementia. This research also shows (for the first time) that an MRI can be used to detect very early signatures of neurological damage in people with high blood pressure, before any symptoms of dementia occur.
Scientists discover protective mechanism against atherosclerosis
June 2018 | Science News
A special type of white blood cells called B2 lymphocytes have been suggested to play a crucial role. For their survival, they need the molecule BAFF. It has been shown, that deletion or blockade of the BAFF receptors at the surface of B2 lymphocytes reduces the development of atherosclerosis in mice.
"Surgery in a Pill" Developed to Mimic Benefits of Bariatric Surgery on Type 2 Diabetes
June 2018 | Science News
RYGB surgery effectively bypasses a significant portion of the stomach and small intestine, and obese T2D patients who undergo the procedure experience “an early and weight-independent improvement or complete resolution of their T2D,” the researchers write. “In fact, 80% of the patients who have RYGB experience early remission of their T2D.
Gene editing just got easier
June 2018 | Science News
Researchers have made CRISPR technology more accessible and standardized by simplifying its complex implementation in a way that offers a broad platform for off-the shelf genome engineering.
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