New protein complex may explain why patients develop resistance to novel anti-cancer drugs
July 2018 | Science News
A team of researchers at the University of Cambridge has identified a protein complex that might explain why some cancer patients treated with the revolutionary new anti-cancer drugs known as PARP inhibitors develop resistance to their medication.
Transfection, Transduction, and CRISPR
July 2018 | Science News
Genetic engineering is not new, however new advances are creating opportunity and reservation amongst those in the scientific community.The technology and ability still remain an amazing feat of scientific ingenuity using the bacterial model as a guide; however, there are still dangers and ethical concerns regarding the editing of genes which should be included in future conversations about the potential of this capability.
Enabling technology in cell-based therapies: Scale-up, scale-out or program in-place
July 2018 | Science News
Technologies are reducing costs and changing the ways in which researchers and clinicians process and use therapeutic cells.
Mixed mRNA Tails Less Easily Docked
July 2018 | Science News
For mRNA molecules, degradation is inevitable, but it may be delayed. One way to extend the lives of mRNA molecules is to give them longer protective tails, which give degradative enzymes something to chew on before they bite into anything vital. The tails can also be made less digestible by ensuring that they are mixed, that is, composed of different nucleotides, not just adenosines.
Protective qualities of 'good cholesterol' reduce after menopause
July 2018 | Science News
Levels of high density lipoprotein (HDL) cholesterol, which is known for its cardioprotective role, may not accurately represent cardiovascular risk in older women, according to research published today in 'Arteriosclerosis, Thrombosis, and Vascular Biology'.
Extra Vinculin Keeps Heart Cells Shapely, Keeps Aging Hearts in Shape
July 2018 | Science News
A structural protein called vinculin reinforces the heart’s extracellular scaffolding. It also helps the heart’s contractile proteins stay organized, so that heartbeats stay strong. UCSD scientists found using the rapidly aging fly system, the cardiac-specific vinculin overexpression increases heart contractility, maximal cardiac mitochondrial respiration, and organismal fitness with age.
Homogenous BTK occupancy assay used in tirabrutinib clinical studies
July 2018 | Science News
A time-resolved fluorescence resonance energy transfer-based Bruton's tyrosine kinase (BTK) occupancy assay that can measure target engagement in peripheral blood mononuclear cells (PBMCs) and in lymph-node and bone-marrow samples. The assay provides accurate, quantitative assessment of BTK occupancy and currently is in use in ongoing tirabrutinib clinical studies.
Testosterone research brings new hope for cancer patients
July 2018 | Science News
Dr. Melinda Sheffield-Moore, professor and head of the Department of Health and Kinesiology, along with researchers at University of Texas Medical Branch, recently published research in the Journal of Cachexia, Sarcopenia and Muscle showing that the hormone testosterone is effective at combating cachexia in cancer patients and improving quality of life.
Researchers reveal massive genome havoc in breast cancer
July 2018 | Science News
In cancer cells, genetic errors wreak havoc. Misspelled genes, as well as structural variations -- larger-scale rearrangements of DNA that can encompass large chunks of chromosomes -- disturb carefully balanced mechanisms that have evolved to regulate cell growth.
Brain function partly replicated by nanomaterials
July 2018 | Science News
Molecular/carbon nanotube network devices enable artificial spiking neurons that mimic nerve impulse generation.
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