Individual stress susceptibility and glucose metabolism are linked to brain function
October 2018 | Science News
Researchers have now discovered that stress-induced mental disturbances in mice are directly linked to abnormal glucose metabolism. Normalizing the stress-induced alterations in glucose levels, using the anti-diabetic drug empagliflozin, restored spatial memory as well as long-term glucose metabolism.
Peptide successfully exploits Achilles' heel of Zika virus
October 2018 | Science News
Scientists have engineered an antiviral peptide that exploits the Zika virus at its Achilles' heel -- the viral membrane -- hence stopping the virus from causing severe infections.
How a single mutation can devastate cellular function.
October 2018 | Science News
A professor of neuroscience at the University of Wisconsin-Madison has shown how a single mutation in a protein found in astrocytes reproduces fibrous globs that devastate cellular function.
New mechanism of action in a first-line drug for diabetes
October 2018 | Science News
Researchers have discovered a mechanism of action underlying a widely used diabetes drug, which may expand its indications for use, as well as open new inroads in pharmaceutical development.
Drug Uptake Gets a Boost in Hard-to-Reach Pancreatic Cells
October 2018 | Science News
ASOs are short (14–20 nucleotides), synthetic, single-stranded oligodeoxynucleotides that can alter RNA and modify protein expression. Recent advances have been made to improve their potency, efficacy, stability, and pharmacokinetic properties.
Potential Drug Target for Tactile Allodynia
October 2018 | Science News
A new protein found in neuronal cells was identified by researchers at Scripps Research to be implicated in tactile allodynia; a painful sensation caused by light touch and often associated with neuropathy.
Cancer Can Change Neutrophils' Behavior Influencing Them to Support Tumor Growth
October 2018 | Science News
Scientists say tumors recapitulated gene-expression and immune-infiltrate features of human squamous NSCLC; such features included enrichment of tumor-associated neutrophils (TANs) and decreased expression of NKX2-1, a transcriptional regulator that specifies alveolar cell fate.
Scientists create synthetic tissue capable of synchronized beating
October 2018 | Science News
A team of chemists at the University of Bristol have developed a prototissue that is capable of synchronized beating when it is heated and cooled.
Many cases of dementia may arise from non-inherited DNA 'spelling mistakes'
October 2018 | Science News
Only a small proportion of cases of dementia are thought to be inherited -- the cause of the vast majority is unknown. Now a team of scientists believe they may have found an explanation: spontaneous errors in our DNA that arise as cells divide and reproduce.
Novel Parkinson’s Therapies Possible with New Mouse Model
October 2018 | Science News
The new tetramer-abrogating mouse displayed key PD-like changes, including age-dependent αS aggregation in altered neurons and distinctive abnormal movements. These changes were all derived from preventing normal αS tetramer formation. These findings strongly suggest that tetramers are required for the normal state of αS in the brain.
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All products are For Research Use Only. Not for use in diagnostic or therapeutic uses. Do not use in humans.