Nasal delivery of leptin hormone may help ease breathing problems during sleep
November 2018  |  Science News
Research has shown that leptin is essential in regulating breathing, and can successfully treat sleep-disordered breathing symptoms in obese mice lacking leptin. However, mice with diet-induced obesity are resistant to the leptin hormone and failed to respond when leptin was injected into the belly (or abdomen).
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How melanoma evades targeted therapies
November 2018  |  Science News
Researchers say that about 13-30 percent of melanomas become resistant to RAF-inhibiting drugs because of a difference in how those cells produce and process the BRAF protein.
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Potential Path for Countering Oxidative Stress Revealed
November 2018  |  Science News
Researchers identified a small molecule capable of activating the antioxidant response—a potential therapy for a range of diseases involving oxidative stress such as chronic kidney disease, neurodegeneration, and autoimmune disease.
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Novel Two-Pronged Method Targets Cancer Cells’ Telomerase and Chromosomes
November 2018  |  Science News
Scientists hope to identify cancer drugs that work in a two-pronged approach—by inducing errors when cancer cells divide packages of their DNA, known as chromosomes as well as inhibiting a key protein in cancer cells, known as telomerase.
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RNA defects linked to multiple myeloma progression in high risk patients
November 2018  |  Science News
Researchers have uncovered an association between RNA abnormalities and multiple myeloma progression. The findings offer novel insights for new, effective therapeutic strategies to be developed.
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Cytostatic Drug Proved Potent For Cancer
October 2018  |  Science News
Cytostatic drug, consisting of therapeutically active molecules that is linked to specific antibodies can treat tumors. Such novel conjugates are made from antibodies and a protein that inhibits kinesin spindle formation.
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Groundbreaking Khíron chip enables fast, accurate intra-tissue measurement
October 2018  |  Science News
Khíron chip enables fast, accurate intra-tissue measurement and continuous nutrient and oxygen supply through all tissue layers for the first time. And it is set to unlock the potential of next-generation cell culture models in disease modeling and preclinical studies.
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Evidence Mounts That Eye Scan May Detect Early Alzheimer’s
October 2018  |  Science News
The researchers show that the small blood vessels in the retina at the back of the eye are altered in patients with Alzheimer’s. Results from two studies show that a new, non-invasive imaging device can see signs of Alzheimer’s disease in a matter of seconds.
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UVA researchers devise new way to unravel complex mysteries of the microbiome
October 2018  |  Science News
Researchers have developed a crystal ball to predict how microorganisms will interact and the ripple effects those interactions will have. Scientists can hope to manipulate the microbiome, as the organisms are collectively known, to cure disease and improve human health.
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Anti-Obesity "Biochemical Cigarette" Exploits Body's Responses to Cold and Smoking
October 2018  |  Science News
Researchers in Europe and Australia have developed an anti-obesity “chemical cigarette” that exploits the body’s natural responses to both cold exposure and smoking. The new approach uses two chemicals to boost energy expenditure and fat burning, while simultaneously dampening appetite, improving lipid metabolism, and reversing glucose intolerance.
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