Researchers demonstrate how manganese produces parkinsonian syndrome
January 2019 | Science News
Researchers have demonstrated the consequences of a mutation responsible for a hereditary parkinsonian syndrome: accumulated manganese in the cells appears to disturb protein transport.
Sugary stent eases suturing of blood vessels, 3D-printed design ups speed, precision of surgical procedure
January 2019 | Science News
Reconstructive procedures and organ transplants demand nimble fingers that can restore blood flow by stitching together millimeter-scale arteries. It's a tough ask and time-consuming task for even the most skilled surgeon.
Mesenchymal stems cells: Vital role in repair of damaged organs
January 2019 | Science News
Researchers discovered that reducing the number of cells participating in condensation process leads to the activation of an intrinsic differentiation program. This prompts MSCs to become cartilage cells even in absence of chondro-inductive growth factors irrespective of donor age and sex.
Light-Up Bacteria Point to Human Cancer-Causing Proteins
January 2019 | Science News
Scientists have harnessed Escherichia coli bacteria to help discover human proteins that can initiate DNA damage, and which may play a role in triggering cells to become cancerous.
Novel biomarker links tumor progression to genome instability
January 2019 | Science News
Study identifies elevated levels of a protein called ubiquilin-4 as a new biomarker for genome instability, it takes part in defending the genome from DNA damage, but too much ubiquilin-4 is harmful. When the amount of ubiquilin-4 rises in tumor cells, the cells become more prone to genome instability, accelerating the tumor's progression and making it resistant to commonly used cancer treatments.
New Findings on the Early Stages of Autism Spectrum Disorder
January 2019 | Science News
Scientists at Salk Institute have gained new insight into the neurological differences between people with and without ASD. Their study created stem cells from normal and ASD patient samples, which showed that ASD-affected stem cells had significantly different rates and patterns of development compared to stem cells unaffected by ASD.
Fungal Brain Infection Found to Induce Memory Impairments
January 2019 | Science News
Some fungal infections, including airway allergic diseases and sepsis, have even been associated with risk of dementia—a neurodegenerative disease that impacts around 50 million people worldwide—which poses the question: how does low-grade Candida albicans, a type of pathogenic yeast, affect the brain?
New Colorectal Cancer Biomarker Could Be Lipid Producing Enzyme
January 2019 | Science News
Investigators at Johns Hopkins have just identified a protein involved in cell proliferation and the development of new blood vessels that could serve as a marker for the early detection of colorectal cancers. The researchers found that the enzyme beta-1,4-galactosyltransferase-V (beta-1,4-GalT-V was increased in human colorectal cancer tumor cells compared with normal tissue.
Inhalable mRNA offers hope for patients with lung disease
January 2019 | Science News
Scientists have reported the success of an inhalable mRNA therapy that can induce the production of a target protein, which in this case was a bioluminescent protein, in the lungs of mice. The study brings hope to patients with chronic pulmonary conditions such as cystic fibrosis.
Disrupted networks link overlapping cognitive deficits in psychiatric disorders
January 2019 | Science News
Psychiatric disorders share common alterations of functional connectivity between three core brain networks involved in cognition, according to a meta-analysis.
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All products are For Research Use Only. Not for use in diagnostic or therapeutic uses. Do not use in humans.