PARP Inhibitors Boost Immune Efficacy
March 2019 | Science News
In a recent research study, precision cancer drugs called PARP inhibitors are previously known to boost the immune system were found to spark a powerful immune response when used against cancer cells with weaknesses in DNA repair.
Obesity Linked with Transcriptional Control of Hunger Gene
March 2019 | Science News
Scientists have identified a genetic mechanism that they claim could play a role in at least 10% of obesity cases. Their mouse studies, backed by human genetic data, provide new insights into transcriptional-level control of the hunger-controlling hormone leptin, and indicate that leptin therapy might lead to weight loss in at least some individuals with treatable forms of the disorder.
Major mutation pattern in cancer occurs in bursts
March 2019 | Science News
Researchers have created a huge resource for investigating the biological mechanisms that cause cancer. The scientists identified which patterns of DNA damage - mutational fingerprints that represent the origins of cancer were present in over a thousand human cancer cell lines. They also revealed that a major mutation pattern found in human cancer, previously linked to a virus-fighting immune response, occurred in bursts in cancer cell lines with long periods of silence in between, but the cause of these mutational bursts remains mysterious.
New mathematical method to map cell regulatory networks
March 2019 | Science News
A new mathematical method developed by researchers at Cincinnati Children's and New York University may soon make it much easier to conduct more of the complex data analysis needed to drive advances in the exploding field of personalized medicine.
Calm State of Stem Cells Preserves Regenerative Capacity in Aging Brain
March 2019 | Science News
have been able to rejuvenate stem cells in the brain of aging mice. The revitalised stem cells improve the regeneration of injured or diseased areas in the brain of old mice. The researchers expect that their approach will provide fresh impetus in regenerative medicine and facilitate the development of stem cell therapies.
Neuronal Identity Crisis in the Hypothalamus can Lead to Obesity
March 2019 | Science News
Researches are working to understand the physiological changes that occur both before and while people are overweight. Some of those changes might happen in the brain, which has a critical role in regulating when we feel hungry, and when we feel full.
Anticancer CAR-T Cells More Effective When Less Exhausted
February 2019 | Science News
Scientists suggest that CAR-T cells engineered to lack a family of three transcription factors don’t develop T-cell exhaustion and so are better at fighting cancer. Initial in vivo studies showed that tumor-bearing mice treated using Nr4a transcription factor-deficient CAR-T cells developed smaller tumors and lived longer than animals treated using CAR-T cells that hadn’t been modified.
Detecting cyanide exposure
February 2019 | Science News
Cyanide exposure can happen occupationally or in low levels from inhaling cigarette smoke -- or from being poisoned by someone out to get you. The effects are fast and can be deadly. But because cyanide is metabolized quickly, it can be difficult to detect in time for an antidote to be administered. Now, in an animal study in ACS' Chemical Research in Toxicology, researchers report a new precise and accurate biomarker of cyanide exposure.
Hip fractures may serve as first sign of undiagnosed Alzheimer’s disease
February 2019 | Science News
The researchers say that brain alterations that lead to poor balance in older people may underpin both increased risk of hip-fracturing falls and Alzheimer’s disease, and that hip fracture itself may therefore serve as a first sign of undiagnosed disease.
MRI Calcium Imaging Peers Deep into the Brain
February 2019 | Science News
Researchers have now devised a new way to image calcium activity that is based on magnetic resonance imaging (MRI) and allows them to peer much deeper into the brain. Using this technique, they can track signaling processes inside the neurons of living animals, enabling them to link neural activity with specific behaviors.
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All products are For Research Use Only. Not for use in diagnostic or therapeutic uses. Do not use in humans.