New CRISPR Tool Described as a DNA Shredder with a Motor
April 2019 | Science News
Scientists reported the development of a new CRISPR-based tool that acts like a shredder, able to remove long stretches of DNA in human cells with programmable targeting. They describe how they succeeded in getting a different kind of CRISPR-Cas system called type I CRISPR-Cas3 to work as long-range DNA editing tool in human cells.
Leukocytes Use Their Nucleus as a Ruler to Find the Best Way Forward
April 2019 | Science News
Mobile cells move around obstacles in dense tissue by selecting for larger pore sizes, according to a recent study published.
Tweaked Beer Hop Compound: Thwarts Cancer, Less Estrogen
April 2019 | Science News
Hops, which contain compounds that add bitterness to beer, also contains a compound that brings bitter consequences to cancer cells, slowing their proliferation and even killing them outright. The anticancer compound from hops is called xanthohumol (XL), and it has been modified by scientists who hope to heighten its benefits while lowering its harms.
Labeling proteins with ubiquitin paves new road to cell regulation research
April 2019 | Science News
Human cells have a sophisticated regulatory system at their disposal: labeling proteins with the small molecule ubiquitin. scientists have succeeded in marking proteins with ubiquitin in a targeted manner, in test tubes as well as in living cells. This procedure opens the door to explore the inner workings of this vital regulatory system.
Exosomes from Blood Carry RNA Signatures of Liver Cancer
April 2019 | Science News
In an effort to detect the cancer as early as possible, cirrhosis patients get ultrasounds and blood tests every six months to look for signs of tumors.. A small study finds that the tiny extracellular vesicles from patients with hepatocellular carcinoma have RNA content distinct from patients with cirrhosis only.
"Wearable" Device Captures Cancer Cells From Blood
April 2019 | Science News
A prototype wearable device, tested in animal models, can continuously collect live cancer cells directly from a patient’s blood. Developed by a team of engineers and doctors, it could help doctors diagnose and treat cancer more effectively.
Scientists identify two, extremely rare genetic variants linked to Alzheimer disease
March 2019 | Science News
Researchers have identified two, extremely rare genetic variants linked to Alzheimer disease (AD) for the first time. Mutations in NOTCH3 and TREM2 have been associated with Alzheimer's Disease.
Researchers Analyze Epigenetic Signatures to Diagnose Rare Diseases
March 2019 | Science News
A number of rare diseases show unique epigenetic patterns across the genome. Scientists have developed a computational tool that can diagnose 14 rare, hereditary disorders based on a patient’s episignature.
Tumor-promoting enzymes USP25 and USP28: Substantial differences identified
March 2019 | Science News
Researchers have solved the structures of the cancer-promoting enzymes USP25 and USP28, and identified significant differences in their activities. Both enzymes promote the growth of various tumors. The results could benefit towards the development of new, low-side-effects anticancer drugs.
Prostate Cancer “Spews” Tumor-Promoting Protein on Neighbors
March 2019 | Science News
Scientists have shown how prostate cancer cells release a protein that is taken up by surrounding normal and cancer cells, and which may promote tumor growth and help protect the cancer from the body’s immune system.
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