Biological “Barrier” Keeps Cancer at Bay
May 2019 | Science News
Activin B is one of the activin proteins. It binds and activates a receptor called ALK7 - a member of the tumor growth factor beta (TGFß) receptors superfamily. When activated, ALK7 triggers a domino effect of molecular and biochemical reactions (a "signaling pathway") that result in various changes across the cell.
Liquid Biopsies Can Point to Best Ovarian Cancer Treatment
May 2019 | Science News
Scientists reported that they were able to use ctDNA shed by ovarian tumors to identify clinically actionable mutations.
What Does It Look Like to “Turn On” a Gene?
May 2019 | Science News
Only recently have scientists directly witnessed this most pivotal of events in biology, thanks to new technology that allows them to observe the process in living cells. It’s teaching them a lot.
Immunotherapy Sensitizes Tumors to Iron-dependent Cell Death
May 2019 | Science News
Researchers looked at a little-understood type of cell death called ferroptosis. They found ferroptosis occurs in tumor cells and plays a role in cancer immunity, suggesting the potential of targeting this pathway to improve immunotherapy treatments.
Researchers grow cells in 'paper organs'
May 2019 | Science News
Long before scientists test new medicines in animals or people, they study the effects of the substances on cells growing in Petri dishes. However, a 2D layer of cells is a poor substitute for the much more complex 3D structure of tissues in organs. Now, researchers reporting in the ACS journal Nano Letters have used a 3D printer to make paper organs, complete with artificial blood vessels, that they can populate with cells.
Restoring brain function in mice with symptoms of Alzheimer's disease
May 2019 | Science News
A study in mice shows that selectively removing cells that are no longer dividing from the brains of mice with a form of Alzheimer's disease can reduce brain damage and inflammation, and slow the pace of cognitive decline. These findings add to evidence that such senescent cells contribute to the damage caused by Alzheimer's disease in people.
By rewiring circuits, brain stimulation sharpens memory of older people
April 2019 | Science News
Team of scientists used jolts of weak electrical stimulation/currents applied to the scalp to synchronize waves in the prefrontal and temporal cortex - two brain areas involved in memory and cognition. After about 25 minutes of stimulation, participants were more accurate at identifying changes in the images compared to prior to the stimulation; their working memory was boosted.
Unmanned aircraft delivered kidney for transplant
April 2019 | Science News
In a first-ever advancement in human medicine and aviation technology, an unmanned aircraft has delivered a donor kidney to surgeons for successful transplantation into a patient with kidney failure.
Cancer Suppressing Proteins Found to Have Role in Antibody Production
April 2019 | Science News
Ten-eleven translocation (TET) proteins have long been known to regulate fundamental biological processes and play important roles in embryonic, neuronal, and hematopoietic development. Through their epigenetic regulation of gene expression, they have been largely implicated as cancer suppressive proteins. Researchers have uncovered how the TET2 and TET3 enzymes contribute to the regulation of immunoglobulin class switching and somatic hypermutation during B-cell activation.
Biological machinery of cell's 'executioner' yields secrets of its control
April 2019 | Science News
Researchers by structural biologists have discovered how the cell switches on an executioner mechanism called necroptosis that induces damaged or infected cells to commit suicide to protect the body.
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All products are For Research Use Only. Not for use in diagnostic or therapeutic uses. Do not use in humans.