Biological Cruise Control Engineered into Living Cells
June 2019  |  Science News
Scientists reported that they installed their genetically engineered synthetic controller in living cells. The controller, they emphasized, is tunable and adaptive. This rationally designed integral controller represents a proof-of-concept design that establishes the feasibility of engineering robust homeostasis in synthetic biology.
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Novel lung map reveals new cells responsible for asthma
June 2019  |  Science News
Researchers have mapped the different types of cells in the lungs and identified key differences between healthy airways and airways affected by asthma.The findings could help advance the discovery of new drug targets for the condition.
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Scientists Identify Which Gut Bacteria Interfere With Parkinson's Treatment
June 2019  |  Science News
Scientists discovered one of the first distinct examples of how gut bacteria can interfere with a drug’s pathway through the body. Out of the trillions of possible culprits, the team was able to identify which bacteria degrade the drug and how to stop the interference.
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Breakthrough Synthesis Advances Potent Anti-Cancer Agent
June 2019  |  Science News
What is now known as a "landmark in drug discovery", researchers have synthesized sufficient amount of E7130, a drug candidate from the halichondrin class, and were able to perform studies on the biological activity of the drug along with pharmacological properties for potential therapies.
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Gut Microbe Takes a Share of Our Brain Meds
June 2019  |  Science News
Swallowing a drug can tilt the gut-brain axis, alleviating the symptoms of neurodegenerative diseases such as Parkinson’s. Yet the axis can resist tilting as though its orientation were maintained by hidden sources of inertia.
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Enhanced human Blood-Brain Barrier Chip performs in vivo-like drug and antibody transport
June 2019  |  Science News
Microfluidic Organs-on-Chips (Organ Chips) technology in combination with a developmentally-inspired hypoxia-mimicking approach to differentiate human pluripotent stem (iPS) cells into brain microvascular endothelial cells (BMVECs). The resulting 'hypoxia-enhanced BBB Chip' recapitulates cellular organization, tight barrier functions and transport abilities of the human BBB.
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Scientists Discover Why Arteries Harden & Find a Potential Treatment
June 2019  |  Science News
scientists have found the cellular mechanism that underlies the process of hardening of arteries, and they have also shown that a drug that's already approved for acne can treat the problem.
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“Chatter” Between Cancer and Immune Cells Makes for a “Hot Tumor”
June 2019  |  Science News
Research study has deciphered a complex molecular conversation between cancer and immune cells that is key to orchestrating the successful invasion of tumors by T cells that kill cancer cells.
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Natural Anti-Parkinson’s Mechanism Discovered That Targets Fibrils, Prevents Lewy Bodies
June 2019  |  Science News
The fibrils that clump together in neurons and contribute to the progression of Parkinson’s disease may be undone by a protein complex called SCF. Recently discovered in cultured human cells and evaluated in mouse models of Parkinson’s, SCF is unstable and short-lived, but when it detects fibrils, it marks them for disposal.
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Human body is a mosaic pattern of DNA mutations, say researchers
June 2019  |  Science News
Researchers have discovered that the human body’s 3 trillion cells aren’t clones of a single DNA sequence, as is widely believed. Instead, the cells of the human body contain a plethora of altered DNA, called mutations. These multiply to produce patches of tissue, called “somatic clones,” inside the ‘normal’ tissue. The scientific term for this phenomenon is mosaicism.
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