Genetically Encoded Frankenbody Lights Up Live Cell Imaging
July 2019  |  Science News
Scientists have developed a genetically encoded probe expressly designed to work in living cells using HA frankenbody to precisely quantify the expression of HA-tagged proteins in developing zebrafish embryos.
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Bacteria engineered as Trojan horse for cancer immunotherapy
July 2019  |  Science News
Researchers have engineered a strain of non-pathogenic bacteria that can colonize solid tumors in mice and safely deliver potent immunotherapies, acting as a Trojan Horse that treats tumors from within. The therapy led not only to complete tumor regression in a mouse model of lymphoma, but also significant control of distant, uninjected tumor lesions.
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Study reveals time taken for DNA repair after chemotherapy
July 2019  |  Science News
A team of researchers found that DNA damaged by the widely used chemotherapy drug cisplatin is mostly good as new in noncancerous tissue within two circadian cycles, or two days.
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Genetically Manipulated Virus Destroys Tumor Cells in Mouse Model
July 2019  |  Science News
Scientists have succeeded in using a genetically manipulated virus to destroy tumor cells upon injection into mice with prostate cancer.
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Obesity Takes the Brakes Off Neurological Mechanism that Stops Overeating
June 2019  |  Science News
Scientist reported studies in mice that suggest obesity may dampen the activity of a specific population of neurons in a region of brain that is associated with controlling eating behavior, and so take the brakes off food intake to further fuel pathological eating and obesity.
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Parkinson's Could Begin in the Gut and Travel Via the Vagus Nerve
June 2019  |  Science News
Researchers say they have found additional evidence that Parkinson's disease originates among cells in the gut and travels up the body's neurons to the brain. The study can offer more accurate model in which to test treatments that could prevent or halt Parkinson's disease progression.
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Study shows how gastric stem cells fight colonizing bacteria
June 2019  |  Science News
Researchers describe what happens during a Helicobacter pylori infection of the human stomach. By actively fighting the colonizing bacteria, gastric stem cells protect themselves against damage that can lead to cancer.
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HDAC Inhibitor Found to Sensitize Cancers to Anti-PD1 Therapy
June 2019  |  Science News
Researchers highlight the immunological effects of HDACi on antitumor responses and suggests that optimal treatment efficacy requires personalized design and rational combination based on prognostic biomarkers (e.g., MHCs) and the individual profiles of HDACi.
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'Sugar-coating' proteins to treat pancreatitis?
June 2019  |  Science News
Recent publication showed a mice producing CA19-9--a complex sugar structure that coats many proteins, with unknown function--surprisingly developed severe pancreatitis, making CA19-9 an attractive therapeutic target for pancreatitis.
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Embryonic Stem Cells Commit to Their Fate Earlier Than First Thought
June 2019  |  Science News
The findings represent a new chapter in the study of embryonic stem cell differentiation, a field that could be key to helping scientists and clinicians unlock improved therapies for a range of diseases.
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