Large Animal Organ Crosstalk Study Sheds New Light on Sepsis
August 2019 | Science News
Researchers investigating the metabolic changes across affected organs in a large animal model of sepsis say they have identified both potential common and organ-specific metabolic alterations contributing to the disease process.
Novel T-cell Subset Associated With Type 1 Diabetes
August 2019 | Science News
Study suggests a role for peripheral helper T cells in the development of type 1 diabetes. Researchers demonstrated that the frequency of these cells was increased in blood of both children with recently diagnosed type 1 diabetes as well as healthy, autoantibody-positive children. Importantly, the frequency was most clearly increased in those autoantibody-positive children who later developed type 1 diabetes.
New lipid signaling target may improve T cell immunotherapy
August 2019 | Science News
T cell immunotherapy uses the immune system to kill cancer cells. To increase the efficacy of this new treatment, researchers aimed to discover a master regulator of T cell fate. The signaling lipid sphingosine 1-phosphate (S1P) influences the T cell lineage: high levels of S1P lead to an inhibitory regulatory T cell phenotype, while low levels of S1P lead to a central memory-like phenotype, which exhibit increased anti-cancer functions.
How E. coli knows how to cause the worst possible infection
August 2019 | Science News
Scientists have revealed how E. coli seeks out the most oxygen-free crevices of your colon to cause the worst infection possible. The discovery could one day let doctors prevent the infection by allowing E. coli to pass harmlessly through the body.
Researchers reverse stem cell aging process
August 2019 | Science News
The study shows how older stem cells can be reverted to a younger and healthier state, a novel discovery that has important implications for a number of degenerative diseases and our fundamental understanding of the aging process.
Rare, Inherited Gene Mutation Raises the Risk of Pancreatic Cancer
August 2019 | Science News
Scientists studying a highly cancer-prone family have identified a rare, inherited gene mutation that dramatically raises the lifetime risk of pancreatic and other cancers.
Novel Drug Target for Dilating Microvessels
August 2019 | Science News
Medical scientists have discovered a natural occurring chemical that dilates blood vessels and at the same time signaling larger blood vessels that more blood is needed. They found that the chemical adenosine—known to facilitate dilation—will not function effectively if levels if its inhibitory compound, adenosine kinase, are increased.
Breast Cancer Mortality and Aspirin Use Linked by DNA Methylation
August 2019 | Science News
Researchers have found that the global DNA methylation, and methylation of the promoters for two specific cancer-related genes, may impact on whether prediagnosis aspirin use can influence breast cancer-specific mortality, and death from all causes.
Delivering Cancer Medication Safely to Its Destination
August 2019 | Science News
An innovative technology developed by teams of researchers for treating cancer more selectively and more effectively. The process transforms proteins and antibodies into stable, highly functional drug transporters, with which tumor cells can be detected and killed.
Scientists 3D print full-scale functioning heart components for the first time
August 2019 | Science News
Researchers have developed a new 3D bioprinting method that can produce any part of the heart, from tiny capillaries through to full-scale heart components.Using human cardiac muscle cells, the team could even make a structure that contracts and functions similarly to a real heart.
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All products are For Research Use Only. Not for use in diagnostic or therapeutic uses. Do not use in humans.