Using CRISPR to Track and Image Genome Editing in Real Time
September 2019 | Science News
Researchers were able to track dynamics of gene editing events induced by the CRISPR proteins. This step is extremely important to be able to track gene therapy and the consequences of it, such as chromosomal translocation.
Dengue virus becoming resistant to vaccines and therapeutics due to mutations in specific protein
September 2019 | Science News
Researchers have discovered that the dengue virus changes its shape through mutations in Envelope protein to evade vaccines and therapeutics. The study also gives insights on the types of treatment strategies to use at different stages of infection. This could give rise to new approaches in vaccine development and treatment for dengue disease.
Compound could play a novel role in halting spread of pancreatic cancer
September 2019 | Science News
Investigators have found that nonmuscle myosin IIC (MYH14), a protein activated in response to mechanical stress, helps promote metastatic behavior in pancreatic cancer cells, and that the compound 4-hydroxyacetophenone (4-HAP), known to stiffen myosin IIC-containing cells, can send it into overdrive, overwhelming the ability of cells to invade nearby tissue.
IL-6 and IL-2 Interplay Shown to Affect T Follicular Helper Cell Development
September 2019 | Science News
Researchers show how the interplay of two interleukin signaling proteins, IL-6 and IL-2, affects the development of T follicular helper (Tfh) cells. This interplay may either maintain or disrupt the balancing act of the immune system.
Transplanted brain stem cells survive without anti-rejection drugs in mice
September 2019 | Science News
In experiments in mice, researchers say they have developed a way to successfully transplant certain protective brain cells without the need for lifelong anti-rejection drugs.
Failed cancer drug could potentially be used to treat fibrotic diseases and scleroderma
September 2019 | Science News
Researchers at Johns Hopkins Medicine have improved on this protein and shown that protein called TRAIL selectively kills cells that cause the hardening of skin associated with scleroderma, effectively reversing the condition in mice genetically engineered to mimic the disease.
An Overactive Cerebellum Causes Widespread Problems Across the Brain
September 2019 | Science News
Recently research team through a series of experiments with rats identified that acute cerebellar inflammation puts the structure in an 'overexcited' state, resulting in the animal developing a temporary decrease in motivation and sociability.
CAR T Immunotherapy May Find New Use in Treating Cardiac Fibrosis
September 2019 | Science News
Scientists show the approach can kill cells that cause hardening of heart tissue in mice, the first proof-of-concept of applying the cancer immunotherapy to cardiac fibrosis, for which there are no other therapeutic options.
Proteins Found That Link with Lower Blood Sugar Levels among Obese Type 2 Diabetes Patients
September 2019 | Science News
Researchers have, for the first time, discovered a family of proteins that are associated with lower blood sugar levels among obese patients with type 2 diabetes. Their study showed that patients with type 2 diabetes who have high levels of the protein, IL-36 cytokines, were found to have lower blood sugar levels, implying that those proteins are associated with better control of the patient’s blood sugar levels and their disease.
New research provides hope for people living with chronic pain
September 2019 | Science News
Researchers have been investigating which brain circuits are changed by injury, in order to develop targeted therapies to reset the brain to stop chronic pain.
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All products are For Research Use Only. Not for use in diagnostic or therapeutic uses. Do not use in humans.