APOE Mutation Linked to Protection From Alzheimer’s: Case Study
November 2019  |  Science News
Researchers have identified an APOE genetic mutation that may help mitigate the risk of some forms of Alzheimer’s. The team showed using in vitro experiments that the sequence, known in the scientific literature as the Christchurch variant, stops the protein product of the gene from binding strongly to its usual targets—sugar molecules involved in the accumulation of tau and neuron damage—and could thus have had a protective effect.
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AI Blood Test Can Spot Signs of Brain Tumour To Speed Up Diagnosis
November 2019  |  Science News
Chemical analysis of blood samples, combined with an artificial intelligence program, could speed up the diagnosis of brain tumours according to research presented at the 2019 NCRI Cancer Conference.
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Discovery of 'cellular bike couriers' could shed light on disease spreading mechanisms
October 2019  |  Science News
The new vesicle discovered by scientists is the first to be identified in twenty years and is the smallest known.
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Disruptions in Mitochondrial Quality Control Can Cause Heart Disease
October 2019  |  Science News
Researchers showed that ANT is vital to a process called mitophagy, which helps remove damaged organelles named mitochondria, the powerhouses of the cell. Problems with this quality control mechanism can ultimately lead to heart defects.
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Cell Membrane Protein Identified as "Crucial" in Development of Liver Cancer
October 2019  |  Science News
Researchers have just described for the first time the crucial involvement of a cell membrane protein in the development and progression of liver cancer. This protein, called clathrin, is known for its key role in the process of internalization of molecules from the extracellular space into the cell, called endocytosis.
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Biomarker for schizophrenia can be detected in human hair
October 2019  |  Science News
Researchers have discovered that a subtype of schizophrenia is related to abnormally high levels hydrogen sulfide in the brain. Experiments showed that this abnormality likely results from a DNA-modifying reaction during development that lasts throughout life. In addition to providing a new direction for research into drug therapies, higher than normal levels of the hydrogen sulfide-producing enzyme can act as biomarker for this type of schizophrenia.
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Researchers uncover novel amyloidosis
October 2019  |  Science News
Scientists have discovered a novel amyloid protein that induces amyloidosis in rats. This new amyloid protein is known to be the lipopolysaccharide binding protein (LBP) and accumulated very frequently in the mammary gland of aged rats.
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Epigenetic Targets Described for Treating Alcohol Abuse and Fetal Alcohol Syndrome
October 2019  |  Science News
Researchers have shown how acetate that is produced when the liver breaks down alcohol travels to the brain, where it is involved in epigenetic processes that impact on the expression of genes involved in learning and memory.
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Disrupting key immune regulator boosts anti-tumor immunity, enables cancer clearance
October 2019  |  Science News
Researchers have shown that disrupting a key immune regulator, a gene called PTPN2, boosts anti-tumor immunity and enables cancer clearance in animal models.
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Why Tumor Cells Invade Distant Organs
October 2019  |  Science News
Scientists explain how tumor cells in the blood target a particular organ and may enable the development of treatments to prevent the spread of cancers, known as metastasis.
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