New PD-1 Regulatory Protein in Colorectal Cancer
January 2020 | Science News
Researchers have discovered the protein casitas B lymphoma (c-Cbl) having the ability to degrade the checkpoint protein PD-1, a protein found on T cells that helps keep them from attacking other cells in the body. Manipulating c-Cbl’s ability to regulate expression of PD-1 may be beneficial in the treatment of cancers.
Tau Can Predict Brain Atrophy A Year in Advance
January 2020 | Science News
The results, published Translational Medicine, says that tau drives brain degeneration in Alzheimer's disease more directly than amyloid protein. Despite early misgivings that tau might be impossible to measure in the living brain, scientists recently developed an investigational injectable molecule called flortaucipir -which binds to misfolded tau in the brain and emits a mild radioactive signal that can be picked up by PET scans.
An atomic view of the trigger for the heartbeat
December 2019 | Science News
Atomic-level studies of the architecture of tiny sodium channel proteins, critical to generating electrical signals that start off each beat of the heart, are imparting striking details about their function, malfunctions, disruption by many disease mutations, and response to medication.
Storing Medical Info Below the Skin's Surface
December 2019 | Science News
Researchers have now developed a novel way to record a patient’s vaccination history: storing the data in a pattern of dye, invisible to the naked eye, that is delivered under the skin at the same time as the vaccine.
When Migrating, Cancer Cells Choose the Path of Least Resistance
December 2019 | Science News
The scientists report that metastatic cancer cells may move quickly, but they're lazy in selecting their route. They pick their path based on how much energy will be required; they opt for wider spaces that are easy to navigate over tight, confined spaces, which reduces the amount of energy it takes to get through.
Previously unknown role of dendritic cells in inflammation revealed
December 2019 | Science News
A study has demonstrated that dendritic cells play a key role in inflammation and how TNF inhibitors can prevent them from fighting infections.
RAS Activation Prevents Pancreatic Cancer Cells from Starving
December 2019 | Science News
Researchers explain how changes in the RAS gene, known to encourage the abnormal growth seen in 90% of pancreatic cancer patients, also accelerates a process that supplies the building blocks required for that growth.
Drug Candidates for Alzheimer Disease May Reverse Effects of Aging
December 2019 | Science News
Researchers using mouse models of Alzheimer disease were able to demonstrate that the investigational drug candidates ‘CMS121’ and ‘J147’ will not only improve symptoms of memory impairment by slowing the deterioration of brain cells but can also reverse aging.
Antibiotic Resistance Mechanism Shows Achilles’ Heel
December 2019 | Science News
Researchers have discovered how a protein released by a deadly superbug allows the microorganism to sense and evade attack by the immune system and antibiotic drugs.
New Markers for Triple Negative Breast Cancer
December 2019 | Science News
Two biomarkers - a 44-gene DNA Damage Response (DDIR) signature and stromal tumor-infiltrating lymphocytes (sTILs) - can serve as prognostic markers in people diagnosed with triple negative breast cancer.
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All products are For Research Use Only. Not for use in diagnostic or therapeutic uses. Do not use in humans.