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PicoProbe™ Tyrosine Aminotransferase Activity Assay Kit

April 2018

PicoProbe™ Tyrosine Aminotransferase Activity Assay Kit


MILPITAS, Calif. - April 19, 2018 - PRLog -- Tyrosine Aminotransferase (EC, also known as Tyrosine Transaminase (TAT), is a mitochondrial enzyme encoded by the TAT gene in the nuclear DNA. It catalyzes the transamination of tyrosine by transferring an amine group to an α-ketoglutarate molecule. Tyrosine Aminotransferase is highly expressed in the liver and its deficiency, usually inherited, leads to a buildup of toxic levels of tyrosine in the body called tyrosinemia. Tyrosinemia causes skin and corneal lesions, kidney and liver disorders, and could lead to mental retardation in newborns.  BioVision's PicoProbeTM Tyrosine Aminotransferase Activity Assay Kit is a simple plate-based fluorometric assay for the measurement of TAT activity in biological samples. The transamination of tyrosine by TAT produces glutamate (through the transfer of amine group to α-ketoglutarate), which converts a non-fluorescent probe to a fluorescent product via an enzymatic reaction. The assay can detect as low as 4 µU of tyrosine aminotransferase.

Figure: Determination of TAT activity using BioVision's K486 in rat liver tissue lysate (4.4 µg protein per well) and Jurkat cell lysate (10 µg protein per well).

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About BioVision:

BioVision, Inc. is a privately held Life Science company headquartered in the beautiful San Francisco Bay area. BioVision develops and offers a wide variety of products including assay kits, antibodies, recombinant proteins & enzymes, and other innovative research tools for studying Apoptosis, Metabolism, Cell Proliferation, Cellular Stress, Cell Damage and Repair, Diabetes, Obesity and Metabolic Syndrome, Stem Cell Biology, Gene Regulation, Signal Transduction, and more.

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