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Plasminogen (PLG) Assay Kit (Colorimetric)

December 2020

Plasminogen (PLG) Assay Kit (Colorimetric)

For measuring the Plasminogen in biological samples such as Plasma and study of fibrinolytic system


MILPITAS, Calif. - Dec. 7, 2020 - PRLog -- Plasminogen (PLG) is the inactive precursor of plasmin, a serine protease that degrades many blood plasma proteins including fibrin clots. PLG is processed to plasmin by endogenous activators including tissue plasminogen activator, tPA or urokinase plasminogen activators (uPA) or exogenous activators such as streptokinase. PLG is synthesized in the liver and is mainly present in plasma at a stable concentration of 200 µg/ml. Plasmin play a key role in the degradation of fibrin clots and several constituents of the extracellular matrix. PLG is a central component of the fibrinolytic system and could be a vital contributor in various diseases. Hereditary plasminogen deficiency is a predisposing risk factor for thromboembolic disease whereas acquired PLG deficiency is often seen in severe liver diseases, acute disseminated intravascular coagulation etc. PLG activators have been used in therapeutics and are also known as "clot buster".

BioVision's Plasminogen Assay Kit is a simple, plate based assay for measuring plasminogen levels in biological samples including plasma. In this assay, excess streptokinase is first mixed with plasminogen to form plasminogen-streptokinase complex. The complex then cleaves a specific, synthetic plasmin substrate releasing pNA. The released pNA is quantified by measuring absorbance at 405 nm. The colorimetric signal is directly proportional to the amount of plasminogen in samples. The assay is specific and high-throughput adaptable. The kit can detect as low as 0.2 µg/ml of plasminogen in Samples.

Figures. (a). Plasminogen Standard Curve. (b). Measurement of plasminogen amounts in pooled human platelet poor plasma (10 µl, 1:20 dilution). All assays were performed following the kit protocol.

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About BioVision:

BioVision, Inc. is a privately held Life Science company headquartered in the beautiful San Francisco Bay area. BioVision develops and offers a wide variety of products including assay kits, antibodies, recombinant proteins & enzymes, and other innovative research tools for studying Apoptosis, Metabolism, Cell Proliferation, Cellular Stress, Cell Damage and Repair, Diabetes, Obesity and Metabolic Syndrome, Stem Cell Biology, Gene Regulation, Signal Transduction, and more.

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