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Glycerophosphorylcholine Assay Kit (Colorimetric/Fluorometric) (K433-100)

May 2018

Glycerophosphorylcholine Assay Kit (Colorimetric/Fluorometric) (K433-100)


MILPITAS, Calif. - May 14, 2018 - PRLog -- Glycerophosphorylcholine (GPC), also referred to as alpha-GPC or choline alfoscerate, is a small metabolite and potential dementia treatment. GPC is a breakdown product of phosphatidylcholine, and dysregulation of phospholipid metabolism can alter lipid and metabolite concentrations, leading to health problems such as fatty liver, Gaucher's disease, and Tay-Sachs disease. GPC is also component of seminal fluid and breast milk, and a precursor of the neurotransmitter, acetylcholine. As GPC can efficiently cross the blood-brain barrier, it has been hypothesized as a treatment for Alzheimer's disease and other forms of dementia. In such cases, GPC serves as a biomarker for lipid membrane decomposition. BioVision's Glycerophosphorylcholine Assay Kit allows a quick and sensitive means to determine GPC concentration in a biological sample. The assay is robust and specific, with a GPC enzyme mix converting GPC in the sample into an intermediate that is then utilized to quantitatively generate signal using the GPC Developer mix and GPC Probe. The included Sample Clean-Up Mix allows the user to avoid high background from choline, which is present at high levels in many biological fluids. The assay is rapid, simple, high throughput compatible, and can detect GPC concentrations as low as 0.1 µM in tissue lysates and other samples such as breast milk and seminal plasma.

Figure: Determination of total GPC concentration in Liver lysate, Human Milk, and Seminal Fluid using K433-100. For this experiment, 100 mg rat liver was homogenized and prepared according to the kit protocol. Breast Milk and Seminal Plasma were prepped according to the above protocol and treated with Sample Clean-Up Mix

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About BioVision:
BioVision, Inc. is a privately held Life Science company headquartered in the beautiful San Francisco Bay area. BioVision develops and offers a wide variety of products including assay kits, antibodies, recombinant proteins & enzymes, and other innovative research tools for studying Apoptosis, Metabolism, Cell Proliferation, Cellular Stress, Cell Damage and Repair, Diabetes, Obesity and Metabolic Syndrome, Stem Cell Biology, Gene Regulation, Signal Transduction, and more.

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