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Fructose-1,6-Bisphosphatase Inhibitor Screening Kit (K399-100)

August 2018

Fructose-1,6-Bisphosphatase Inhibitor Screening Kit


MILPITAS, Calif. - Aug. 7, 2018 - PRLog -- Fructose-1,6-bisphosphatase (FBP1) is responsible for the conversion of fructose-1,6-bisphosphate to fructose-6-phosphate in the rate determining step of gluconeogenesis. FBP1 is a tetramer that plays a role in regulating adiposity and appetite. FBP1 is a vital key player in glucose regulation processes the secretion of insulin in pancreatic beta-cells. Research shows FBP1 can also regulate appetite: there is a positive correlation between protein expression and nutrient excess and regulates satiety hormones and reduces the presence of neuropeptides that modulates appetite; thus it could be used a mechanism to products that can help reduce body weight. FBP1 has emerged as an important therapeutic target to treat diabetes type 2 to regulate glucose levels during gluconeogenesis. In BioVision's FBP1 Inhibitor Screening Kit (K399-100), human FBP1 hydrolyzes fructose-1,6-bisphosphate to fructose-6-phosphate which oxidizes and reacts with a fluorogenic probe, that is detected at Ex/Em= 535/587 nm. The assay is fast, sensitive, high-throughput compatible and provides a quick and sensitive way for screening, studying and characterizing potential novel inhibitors of FBP1.

Figure: Inhibition of FBP1 activity by the control inhibitor, with an IC50 of 4 µM.  Assay performed following kit protocol (K399-100).

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BioVision, Inc. is a privately held Life Science company headquartered in the beautiful San Francisco Bay area. BioVision develops and offers a wide variety of products including assay kits, antibodies, recombinant proteins & enzymes, and other innovative research tools for studying Apoptosis, Metabolism, Cell Proliferation, Cellular Stress, Cell Damage and Repair, Diabetes, Obesity and Metabolic Syndrome, Stem Cell Biology, Gene Regulation, Signal Transduction, and more.

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