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Choline Kinase (ChoK) Activity Assay Kit (K476-100)

June 2018

Choline Kinase (ChoK) Activity Assay Kit (K476-100)


MILPITAS, Calif. - June 13, 2018 - PRLog -- Choline kinase (E.C. is an enzyme that catalyzes the first reaction in the CDP-choline pathway for the synthesis of phosphatidylcholine, a membrane phospholipid. This transferase, utilizes Mg2+ as a cofactor in order to transfer a phosphate moiety from ATP to choline molecules forming phosphocholine. In humans, there are two isozymes, Choline Kinase A and B. Both proteins share more than 60% in homology. Choline Kinase plays pivotal roles in different human diseases: elevated Choline kinase A expression has been found in breast, lung, colorectal, prostate and bladder tumor tissues whereas choline kinase B is suggested to be involved in muscular dystrophy. In BioVison's Choline Kinase Activity Assay Kit, choline is phosphorylated by choline kinase producing a series of intermediates, which react with the fluorometric probe generating a strong flurorescence signal (Ex/Em = 535/587 nm). The signal is directly proportional to choline kinase activity present in the biological sample. The assay is fast, sensitive, reproducible and is suitable for measuring choline kinase activity in different cells and other biological samples This kit can detect as low as 0.5 μM of choline kinase activity.

Figure: Activity of ChoK in various biological samples was determined using K476-100.

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About BioVision:
BioVision, Inc. is a privately held Life Science company headquartered in the beautiful San Francisco Bay area. BioVision develops and offers a wide variety of products including assay kits, antibodies, recombinant proteins & enzymes, and other innovative research tools for studying Apoptosis, Metabolism, Cell Proliferation, Cellular Stress, Cell Damage and Repair, Diabetes, Obesity and Metabolic Syndrome, Stem Cell Biology, Gene Regulation, Signal Transduction, and more.

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