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Caspase-3 Activity Assay Kit II (Fluorometric)

January 2019

Caspase-3 Activity Assay Kit II (Fluorometric)


MILPITAS, Calif. - Jan. 15, 2019 - PRLog -- Caspase-3 ( is a cysteine protease that cleaves the C-terminal of an Aspartate residue at the P1 position. The cleavage event is a critical step in the downstream signaling and amplification of apoptosis, or programmed cell death. Apoptosis is a tightly regulated event that plays a central role in the development and homeostasis of multi-cellular organisms.
BioVision's Caspase-3 Fluorometric Activity Assay Kit II allows the detection and quantification of Caspase-3 Activity by using a synthetic substrate DEVD-AFC (AFC: 7-amino-4-trifluoromethyl coumarin), which upon cleavage by Caspase-3, will emit a strong, stable fluorometric signal (Ex/Em= 400/505 nm). The assay is sensitive, fast and allows for the high-throughput quantification of Caspase-3 Activity in cell lysate or adherent cells and can be used to evaluate induction of apoptosis and/or evaluation of apoptosis inhibitors. As little as 11.25 mU of activity per well and less than 500 apoptotic cells can be detected.

Figure: Specific Activity of Caspase 3 in HeLa cells using kit protocol

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About BioVision:

BioVision, Inc. is a privately held Life Science company headquartered in the beautiful San Francisco Bay area. BioVision develops and offers a wide variety of products including assay kits, antibodies, recombinant proteins & enzymes, and other innovative research tools for studying Apoptosis, Metabolism, Cell Proliferation, Cellular Stress, Cell Damage and Repair, Diabetes, Obesity and Metabolic Syndrome, Stem Cell Biology, Gene Regulation, Signal Transduction, and more.

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