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Acid Sphingomyelinase Assay Kit II (Colorimetric)

January 2019

Acid Sphingomyelinase Assay Kit II (Colorimetric)

Complete kit that allows the measurement of Acid Sphingomyelinase in biological samples


MILPITAS, Calif. - Jan. 25, 2019 - PRLog -- Sphingomyelinase (SMase) cleaves sphingomyelin to produce hosphorylcholine and ceramide. The activation of SMase leads to increased production of ceramide, which acts as a lipid second messenger.There are five distinct types of SMases. Deficiency in Acid SMase (ASMase) leads to Niemann-Pick disease type A and B.
BioVision's Acid Sphingomyelinase Activity Assay Kit provides a simple
and sensitive method for measuring ASMase enzymatic activity using colorimetry (OD 570 nm). In this assay, ASMase converts its substrate, sphingomyelin to phosphorylcholine and ceramide at pH 5.0; subsequently, phosphorylcholine is utilized in a series of reactions culminating in color formation from a highly specific probe. This high-throughput adaptable assay kit can detect ASMase activity as low as 3 mU/ml in a variety of samples.

Figure:  ASMase activity of serum and macrophage cell lysate (1 µg/µl). Assays were performed following the kit protocol.

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About BioVision:
BioVision, Inc. is a privately held Life Science company headquartered in the beautiful San Francisco Bay area. BioVision develops and offers a wide variety of products including assay kits, antibodies, recombinant proteins & enzymes, and other innovative research tools for studying Apoptosis, Metabolism, Cell Proliferation, Cellular Stress, Cell Damage and Repair, Diabetes, Obesity and Metabolic Syndrome, Stem Cell Biology, Gene Regulation, Signal Transduction, and more.

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