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Netarsudil dihydrochloride

A potent, selective ROCK inhibitor
Catalog #: B2387
SKU-Size Size Price Qty
B2387-5 5 mg
B2387-25 25 mg
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Product Details

Alternate Name [4-[(2~{S})-3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl]phenyl]methyl 2,4-dimethylbenzoate;dihydrochloride, AR-13324 hydrochloride
Appearance Crystalline solid
CAS # 1253952-02-1
Molecular Formula C₂₈H₂₉Cl₂N₃O₃
Molecular Weight 526.46
Purity ≥98% by HPLC
Solubility >20 mg/ml in Water
InChi InChI=1S/C28H27N3O3.2ClH/c1-18-3-10-25(19(2)13-18)28(33)34-17-20-4-6-21(7-5-20)26(15-29)27(32)31-24-9-8-23-16-30-12-11-22(23)14-24;;/h3-14,16,26H,15,17,29H2,1-2H3,(H,31,32);2*1H/t26-;;/m1../s1
PubChem CID 66599892
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Netarsudil Hydrochloride (AR-13324) is a Rho kinase (ROCK) inhibitor with norepinephrine transport inhibitory activity that reduces production of aqueous humor. Netarsudil (AR-13324) is a potent, selective ROCK inhibitor with Ki of 4.2 nM for ROCK2; a novel ocular hypotensive agent for the treatment of glaucoma.

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