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A specific agonist of the mouse TLR4 (mTLR4)/myeloid differentiation factor 2 (MD-2) complex
Catalog #: B2756
SKU-Size Size Price Qty
B2756-1 1 mg
B2756-5 5 mg
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Product Details

Alternate Name (αS)-α-[[4-Amino-3-[2-(4-hydroxyphenyl)ethyl]benzoyl]amino]-benzenebutanoic acid 1,1-dimethylethyl ester
Peptide Sequence N/A
Appearance White to off-white solid
CAS # 1622863-21-1
Molecular Formula C₂₉H₃₄N₂O₄
Molecular Weight 474.59
Purity ≥98% by HPLC
Solubility ~15 mg/ml DMSO
SMILES O=C(OC(C)(C)C)[[email protected]@H](NC(C1=CC=C(N)C(CCC2=CC=C(O)C=C2)=C1)=O)CCC3=CC=CC=C3
InChi InChI=1S/C29H34N2O4/c1-29(2,3)35-28(34)26(18-12-20-7-5-4-6-8-20)31-27(33)23-14-17-25(30)22(19-23)13-9-21-10-15-24(32)16-11-21/h4-8,10-11,14-17,19,26,32H,9,12-13,18,30H2,1-3H3,(H,31,33)/t26-/m0/s1
PubChem CID 375690552
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Neoseptin-3 is a Toll-like receptor 4/myeloid differentiation factor 2 (mTLR4/MD-2) agonist (EC50 of 18.5 μM). Neoseptin-3 stimulates the activity of mouse TLR4 (mTLR4)/myeloid differentiation factor 2 (mTLR) independently of CD14 (cluster of differentiation 14). Neoseptin-3 binds to MD2, changes the conformation of MD-2 and facilitates active TLR4/MD-2 dimer formation.

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