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Necrostatin-5

A necroptosis inhibitor
Catalog #: 1865
SKU-Size Size Price Qty
1865-5 5 mg
$70.00
1865-25 25 mg
$265.00
More Sizes Get Quote

Product Details

Alternate Name 3-p-Methoxyphenyl-5,6-tetramethylenothieno[2,3-d]pyrimidin-4-one-2-mercaptoethylcyanide; Nec-5
Appearance White to off-white solid
CAS # 337349-54-9
Molecular Formula C₁₉H₁₇N₃O₂S₂
Molecular Weight 383.49
Purity ≥98% by NMR
Solubility DMSO (~10 mg/ml)
SMILES COC1=CC=C(C=C1)N2C(=O)C3=C(N=C2SCC#N)SC4=C3CCCC4
InChi InChI=1S/C19H17N3O2S2/c1-24-13-8-6-12(7-9-13)22-18(23)16-14-4-2-3-5-15(14)26-17(16)21-19(22)25-11-10-20/h6-9H,2-5,11H2,1H3
InChi Key VGONMECBFMCKBS-UHFFFAOYSA-N
PubChem CID 1913406
MDL Number MFCD01448275
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Inhibits non-apoptotic cell death pathway by inhibition of the death domain receptor-associated adaptor kinase RIP1. Three distinct mechanisms appear to be involved in necroptosis, the alternative active cell death pathway: T-loop dependent inhibition by necrostatin-1; partially T-loop independent inhibition by necrostatin-3 and indirect inhibition of RIP1 by necrostatin-5.


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