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Product Details
| Alternate Name | 3-p-Methoxyphenyl-5,6-tetramethylenothieno[2,3-d]pyrimidin-4-one-2-mercaptoethylcyanide; Nec-5 |
|---|---|
| Appearance | White to off-white solid |
| CAS # | 337349-54-9 |
| Molecular Formula | C₁₉H₁₇N₃O₂S₂ |
| Molecular Weight | 383.49 |
| Purity | ≥98% by NMR |
| Solubility | DMSO (~10 mg/ml) |
| SMILES | COC1=CC=C(C=C1)N2C(=O)C3=C(N=C2SCC#N)SC4=C3CCCC4 |
| InChi | InChI=1S/C19H17N3O2S2/c1-24-13-8-6-12(7-9-13)22-18(23)16-14-4-2-3-5-15(14)26-17(16)21-19(22)25-11-10-20/h6-9H,2-5,11H2,1H3 |
| InChi Key | VGONMECBFMCKBS-UHFFFAOYSA-N |
| PubChem CID | 1913406 |
| MDL Number | MFCD01448275 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Inhibits non-apoptotic cell death pathway by inhibition of the death domain receptor-associated adaptor kinase RIP1. Three distinct mechanisms appear to be involved in necroptosis, the alternative active cell death pathway: T-loop dependent inhibition by necrostatin-1; partially T-loop independent inhibition by necrostatin-3 and indirect inhibition of RIP1 by necrostatin-5.
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