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Necrostatin-1

A necroptosis inhibitor
Catalog #: 1864
SKU-Size Size Price Qty
1864-5 5 mg
$75.00
1864-25 25 mg
$245.00
More Sizes Get Quote

Product Details

Alternate Name 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone; Methylthiohydantoin-DL-tryptophan; Nec-1
Appearance Yellow solid
CAS # 4311-88-0
Molecular Formula C₁₃H₁₃N₃OS
Molecular Weight 259.33
Purity ≥98% by TLC
Solubility DMSO (~25 mg/ml) or EtOH (~ 6 mg/ml)
SMILES CN1C(=O)C(NC1=S)CC2=CNC3=CC=CC=C32
InChi InChI=1S/C13H13N3OS/c1-16-12(17)11(15-13(16)18)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,14H,6H2,1H3,(H,15,18)
InChi Key TXUWMXQFNYDOEZ-UHFFFAOYSA-N
PubChem CID 2828334
MDL Number MFCD00056916
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Inhibits necroptosis, a non-apoptotic cell death pathway. Does not inhibit FAS-induced apoptosis and has no effect on apoptotic morphology. Inhibits RIP1 kinase, the key upstream kinase involved in the activation of necroptosis (EC₅₀ = 180 nM).


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