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Necrosis Inhibitor, Necrox-5

based on 1 citations in multiple journalsNecrosis Inhibitor, Necrox-514.1 4
A necrosis inhibitor
Catalog #: 2229
SKU-Size Size Price Qty
2229-1 1 mg
2229-5 5 mg
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Product Details

Alternate Name [5-(1,1-Dioxo-thiomorpholin-4-ylmethyl)-2-phenyl-1H-indol-7-yl]-(tetrahydro-pyran-4-ylmethyl)-amine, dihydrochloride
Appearance Light pink solid
Molecular Formula C₂₅H₃₁N₃O₃S₂ ∙ 2CH₄O₃S
Molecular Weight 645.83
Purity ≥95% by HPLC
Solubility DMSO (>10 mg/ml) or H₂O (>10 mg/ml)
PubChem CID
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A cell-permeable necrosis inhibitor that displays antioxidant property. It localizes mostly in the mitochondria. Selectively blocks oxidative stress-induced necrotic cell death (0.1 µM NecroX-5 prevented ~50% cell death in H9C2 cells exposed to 400 µM t-BuOOH for 2 hours). Does not protect against staurosporine or etoposide-induced apoptosis. Protects cells against cold shock, hypoxia and oxidative stress in vitro, as well as CCl4 -induced acute liver injury and chronic liver fibrosis in rodent models.

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Wang et al., BNIP3 Upregulation by ERK and JNK Mediates Cadmium-Induced Necrosis in Neuronal Cells. Toxicol. Sci., Aug 2014; 140: 393 - 402.
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