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Necrosis Inhibitor, Necrox-2

based on 1 citations in multiple journalsNecrosis Inhibitor, Necrox-214.1 4
A necrosis inhibitor
Catalog #: 2228
SKU-Size Size Price Qty
2228-1 1 mg
$130.00
2228-5 5 mg
$520.00
More Sizes Get Quote

Product Details

Alternate Name [5-(1,1-Dioxo-thiomorpholin-4-ylmethyl)-2-phenyl-1H-indol-7-yl]-(1-methanesulfonyl-piperidin-4-yl)-amine
Appearance Off-white solid
Molecular Formula C₂₅H₃₂N₄O₄S₂
Molecular Weight 516.67
Purity ≥95% by HPLC
Solubility DMSO (>10 mg/ml)
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A cell-permeable necrosis inhibitor that displays antioxidant property. It localizes mostly in the mitochondria. Selectively blocks oxidative stress-induced necrotic cell death (0.1 µM NecroX-2 prevented ~50% cell death in H9C2 cells exposed to 400 µM t-BuOOH for 2 hours). Does not protect against staurosporine or etoposide-induced apoptosis. Protects cells against cold shock, hypoxia and oxidative stress in vitro.


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Wang et al., BNIP3 Upregulation by ERK and JNK Mediates Cadmium-Induced Necrosis in Neuronal Cells. Toxicol. Sci., Aug 2014; 140: 393 - 402.
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