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Nec-1s

A potent necroptosis inhibitor
Catalog #: 2263
SKU-Size Size Price Qty
2263-1 1 mg
$105.00
2263-5 5 mg
$250.00
More Sizes Get Quote

Product Details

Alternate Name 5-((7-Cl-1H-indol-3-yl)methyl)-3-methylimidazolidine-2,4-dione); 7-Cl-O-Nec-1
Peptide Sequence No
Appearance Yellow solid
CAS # 852391-15-2
Molecular Formula C₁₃H₁₂ClN₃O₂
Molecular Weight 277.71
Purity ≥96% by TLC and LC-MS
Solubility DMSO
SMILES CN1C(=O)C(NC1=O)CC2=CNC3=C2C=CC=C3Cl
InChi InChI=1S/C13H12ClN3O2/c1-17-12(18)10(16-13(17)19)5-7-6-15-11-8(7)3-2-4-9(11)14/h2-4,6,10,15H,5H2,1H3,(H,16,19)
InChi Key WIKGAEMMNQTUGL-UHFFFAOYSA-N
PubChem CID 643953
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A potent necroptosis inhibitor. Displays higher activity in inhibiting necroptosis in Jurkat cells than Nec-1 (Cat. No. 1864) (EC₅₀ = 210 nM versus EC₅₀ = 490 nM), as well as showing no nonspecific cytotoxicity at high concentrations (~100 mM). More useful for in-cell and in vivo experiments compared to Nec-1.


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Scott McComb, Efficient apoptosis requires feedback amplification of upstream apoptotic signals by effector caspase-3 or -7. Sci Adv., July 2019;  31392262.
Gianmaria Liccardi, RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation. Mol Cell, Feb 2019;  30598363.
Jennifer Yinuo Cao, A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity. Cell Rep, Feb 2019;   30726737.
Elodie Lafont, TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation. Nat Cell Biol., Nov. 2018, 30420664.
Kristina K. Durham, et al., ( 2018) High-density lipoprotein protects cardiomyocytes against necrosis induced by oxygen and glucose deprivation through SR-B1, PI3K, and AKT1 and 2, Biochemical Journal, Apr. 2018, 29523748.
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