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NE-100 hydrochloride

A potent antagonist of sigma-1 receptor
Catalog #: B3047
SKU-Size Size Price Qty
B3047-1 1 mg
$60.00
B3047-5 5 mg
$240.00
More Sizes Get Quote

Product Details

Alternate Name N-[2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethyl]-N-propylpropan-1-amine;hydrochloride; 4-Methoxy-3-(2-phenylethoxy)-N,N-dipropylbenzeneethanamine hydrochloride
Appearance White solid
CAS # 149409-57-4
Molecular Formula C₂₃H₃₄ClNO₂
Molecular Weight 391.97
Purity ≥98%
Solubility ~39 mg/ml in DMSO; ~10 mg/ml in water
SMILES CCCN(CCC)CCC1=CC(=C(C=C1)OC)OCCC2=CC=CC=C2.Cl
InChi InChI=1S/C23H33NO2.ClH/c1-4-15-24(16-5-2)17-13-21-11-12-22(25-3)23(19-21)26-18-14-20-9-7-6-8-10-20;/h6-12,19H,4-5,13-18H2,1-3H3;1H
InChi Key ZHGMDXSHODHWHV-UHFFFAOYSA-N
PubChem CID 9952420
MDL Number MFCD00922105
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

NE-100 is a potent antagonist of sigma-1 (σ1) receptor. It inhibits binding of (+)-pentazocine binding to sigma-1 binding sites with an IC₅₀ value of 1.54 nM. NE-100 attenuates phencyclidin induced head-weaving behavior or ataxia in experimental animals. It suppresses ER stress-induced cell death by the upregulation of 78-kDa glucose-regulated protein (GRP78). Modulators of sigma receptors are suggested to show activity against SARS-CoV-2, based on interaction of SARS-CoV-2 proteins Nsp6 and Orf9c with sigma receptors.


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