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NCOA1 Antibody

Polyclonal antibody to detect NCOA1 in human, mouse and rat samples.
Catalog #: 6153
$335.00

Product Details

Cat # +Size 6153-100
Size 100 μg
Antibody Target NCOA1
Alternate Name NCOA1, F­SRC­1, KAT13A, MGC129719, MGC129720, NCoA­1, RIP160, SRC­1, SRC1, bHLHe42, bHLHe74, 6/G9a
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Recombinant protein of human NCOA1
Accession # Q15788
Gene ID 8648
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation 100 µg of antibody in 100 µl PBS containing 0.02% sodium azide, 50% glycerol, pH 7.3
Purification Affinity purified
Species Reactivity Human, mouse, rat
Application Western blot, Immunohistochemistry
Positive Control Western Blot: Testis cell lysates
Application & Usage Western blot: 1:500 – 1:2000, IHC: 1:50 – 1:200.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

There are three members of the steroid receptor co­activator (SRC) family of proteins: SRC­1 (NCoA­1), SRC­2 (TIF2/GRIP1/NCoA­2), and SRC­3 (ACTR /TRAM­1/AIB1). All SRC family members share significant structural homology and function to stimulate transcription mediated by nuclear hormone receptors and other transcriptional activators such as Stat3, NF­κB, E2F1, and p53. Two SRC proteins, SRC­1 and SRC­3, function as histone acetyltransferases. In addition, all three family members can recruit other histone acetyltransferases (CBP/p300, PCAF) and histone methyltransferases (PRMT1, CARM1) to target promoters and cooperate to enhance expression of many genes. The SRC proteins play important roles in multiple physiological processes including cell proliferation, cell survival, somatic cell growth, mammary gland development, female reproductive function, and vasoprotection. SRC­1 and SRC­3 are conduits for kinase mediated growth factor signaling to the estrogen receptor and other transcriptional activators. Seven SRC­1 phosphorylation sites and six SRC­3 phosphorylation sites have been identified, which are induced by steroids, cytokines, and growth factors and involve multiple kinase signaling pathways. Research has shown that all three SRC family members are associated with increased activity of nuclear receptors in breast, prostate, and ovarian carcinomas. According to the literature, SRC­3 is frequently amplified or overexpressed in a number of cancers, and SRC­1/PAX3 and SRC­2/MYST3 translocations are found associated with rhabdomyosarcoma and acute myeloid leukemia, respectively.


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