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NCB-0846

A potent TNIK inhibitor
Catalog #: B2643
SKU-Size Size Price Qty
B2643-1 1 mg
$65.00
B2643-5 5 mg
$255.00
More Sizes Get Quote

Product Details

Alternate Name cis-4-(2-(3H-Benzo[d]imidazol-5-ylamino)quinazolin-8-yloxy)cyclohexanol
Appearance Crystalline solid
CAS # 1792999-26-8
Molecular Formula C₂₁H₂₁N₅O₂
Molecular Weight 375.42
Purity ≥98% by HPLC
Solubility >30 mg/ml DMSO
SMILES C1CC(CCC1O)OC2=CC=CC3=CN=C(N=C32)NC4=CC5=C(C=C4)N=CN5
InChi InChI=1S/C21H21N5O2/c27-15-5-7-16(8-6-15)28-19-3-1-2-13-11-22-2
InChi Key FYWRWBSYRGSWIQ-UHFFFAOYSA-N
PubChem CID 91801204
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

NCB-0846 is a potent small-molecule TNIK (Traf2 and Nck-interacting protein kinase) inhibitor, having anti-Wnt activity and suppressing Wnt-driven intestinal tumorigenesis. Also inhibits FLT3, JAK3, PDGFRa, TRKA, CDK2/CycA2, and HGK. NCB-0846 suppresses the growth of tumors established by inoculating HCT116 cells into immunodeficient mice


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