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Nanaomycin A

A selective DNA methyltransferase 3B (DNMT3B) inhibitor
Catalog #: 2790
SKU-Size Size Price Qty
2790-1 1 mg
$135.00
2790-5 5 mg
$435.00
More Sizes Get Quote

Product Details

Alternate Name 2-[(1S, 3R)-9-hydroxy-1-methyl-5,10-dioxo-3,4-dihydro-1H-benzo[g]isochromen-3-yl]acetic acid; Nanafrocin, Nanafrocine, Nanafrocinum, Rosanomycin A
Appearance Crystalline solid
CAS # 52934-83-5
Molecular Formula C₁₆H₁₄O₆
Molecular Weight 302.28
Purity ≥98% by HPLC
Solubility DMSO (~10 mg/ml)
SMILES CC1C2=C(CC(O1)CC(=O)O)C(=O)C3=C(C2=O)C(=CC=C3)O
InChi InChI=1S/C16H14O6/c1-7-13-10(5-8(22-7)6-12(18)19)15(20)9-3-2-4-11(17)14(9)16(13)21/h2-4,7-8,17H,5-6H2,1H3,(H,18,19)
InChi Key ZCJHPTKRISJQTN-UHFFFAOYSA-N
PubChem CID 40586
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Nanaomycin A is a selective DNA methyltransferase 3B (DNMT3B) inhibitor. It induces antiproliferative effects in three different tumor cell lines originating from different tissues. Nanaomycin A treatment reduces the global methylation levels in all three cell lines and reactivates transcription of the RASSF1A tumor suppressor gene.


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