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NAALDase Inhibitor, PMPA

A potent NAALADase inhibitor
Catalog #: 2478
SKU-Size Size Price Qty
2478-5 5 mg
2478-25 25 mg
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Product Details

Alternate Name 2-(Phosphonomethyl)pentane-1,5-dioi​c acid; PMPA
Appearance White solid
CAS # 173039-10-6
Molecular Formula C₆H₁₁O₇P
Molecular Weight 226.12
Purity ≥95% by NMR
Solubility H₂O (>20 mg/ml)
InChi InChI=1S/C6H11O7P/c7-5(8)2-1-4(6(9)10)3-14(11,12)13/h4H,1-3H2,(H,7,8)(H,9,10)(H2,11,12,13)
PubChem CID 10130754
Handling Protect from moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


PMPA is a highly potent and selective inhibitor of NAALADase (N-acetylated-alpha-linked-acidic dipeptidase or glutamate carboxypeptidase II or GCPII) with a Ki value of 275 pM. Displays robust neuroprotective activity in both in vitro and in vivo models of ischemia.

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