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A cell-permeable inhibitor of α-ketoglutarate-dependent enzymes
Catalog #: B1084
SKU-Size Size Price Qty
B1084-10 10 mg
B1084-50 50 mg
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Product Details

Alternate Name 2-(Carboxymethylamino)-2-oxoacetic acid
Appearance White Solid
CAS # 5262-39-5
Molecular Formula C₄H₅NO₅
Molecular Weight 147.1
Purity ≥95% by HPLC
Solubility DMSO (~10 mg/ml)
InChi InChI=1S/C4H5NO5/c6-2(7)1-5-3(8)4(9)10/h1H2,(H,5,8)(H,6,7)(H,9,10)
PubChem CID 3080614
MDL Number MFCD00913253
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


N-Oxalylglycine, the amide analog of α-ketoglutarate, is a cell-permeable inhibitor of α-ketoglutarate-dependent enzymes, including JMJD2A, JMJD2C, and JMJD2E (IC₅₀s = 250, 500, and 24 μM, respectively). It can also inhibit the prolyl hydroxylase domain-containing proteins PHD1 and PHD2 with IC₅₀ values of 2.1 and 5.6 μM, respectively.

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