N-Cadherin Antibody (Clone # EPR1791-4)

Monoclonal Antibody to detect N Cadherin in human samples.
Catalog #: 6781 | abID:

Product Details

Cat # +Size 6781-50
Size 50 μl
Antibody Target N-Cadherin
Alternate Name CDH2, CDHN, NCAD, Cadherin-2, CDw325
Host Rabbit
Antibody Type Monoclonal
Isotype Rabbit IgG
Immunogen A synthetic peptide corresponding to residues in the extracellular region of human N-Cadherin was used as an immunogen.
Accession # P19022
Gene ID 1000
Appearance Colorless liquid
Formulation In 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Species Reactivity Human, Mouse, Rat.
Application Western blot.
Positive Control Western blot:Huvec, C6 and Hela cell lysates.
Application & Usage WB: 1:1000 – 1:10000.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Thy1 is a GPI-anchored, developmentally regulated protein involved in various signaling cascades that mediate neurite outgrowth, T cell activation, tumor suppression, apoptosis, and fibrosis. It is highly expressed on the surface of adult neurons and is thought to play a role in modulating adhesive and migratory events, such as neurite extension. Decreased Thy1 expression is associated with the development of epithelial ovarian cancer, revealing its role as a putative tumor suppressor gene of human ovarian cancer. Thy1 knockout mice have impaired cutaneous immune responses and abnormal retinal development. Thy1 is epigenetically regulated or deregulated in some disease states, such as pulmonary fibrosis. The potentially reversible hypermethylation of the Thy1 promoter offers the possibility of novel therapeutic options in this disease.


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