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Product Details
| Alternate Name | (2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid |
|---|---|
| Appearance | Off-white solid |
| CAS # | 35891-70-4 |
| Molecular Formula | C₂₁H₃₉NO₆ |
| Molecular Weight | 401.54 |
| Purity | ≥98% |
| Solubility | DMSO (~20 mg/ml) |
| SMILES | CCCCCCC(=O)CCCCCCC=CCC(C(C(CO)(C(=O)O)N)O)O |
| InChi | InChI=1S/C21H39NO6/c1-2-3-4-10-13-17(24)14-11-8-6-5-7-9-12-15-18(25)19(26)21(22,16-23)20(27)28/h9,12,18-19,23,25-26H,2-8,10-11,13-16,22H2,1H3,(H,27,28)/b12-9+/t18-,19+,21+/m1/s1 |
| InChi Key | ZZIKIHCNFWXKDY-GNTQXERDSA-N |
| PubChem CID | 6438394 |
| MDL Number | MFCD01632772 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
A fungal metabolite with potent immunosuppressant activity that is 10-100 fold more compared to Cyclosporin A (Cat. No. 1522). It inhibits serine palmitoyltransferase (Ki = 0.28 nM) blocking the synthesis of ceramide. It was found to suppress melanoma cell proliferation by cell cycle arrest at the G 2/M phase through decreased sphingolipid levels and increased p53 and p21 (waf1/cip1) expression.
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