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Myriocin (ISP-1)

A potent immunosuppressant
Catalog #: 2567
SKU-Size Size Price Qty
2567-5 5 mg
2567-25 25 mg
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Product Details

Alternate Name (2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid
Appearance Off-white solid
CAS # 35891-70-4
Molecular Formula C₂₁H₃₉NO₆
Molecular Weight 401.54
Purity ≥98%
Solubility DMSO (~20 mg/ml)
InChi InChI=1S/C21H39NO6/c1-2-3-4-10-13-17(24)14-11-8-6-5-7-9-12-15-18(25)19(26)21(22,16-23)20(27)28/h9,12,18-19,23,25-26H,2-8,10-11,13-16,22H2,1H3,(H,27,28)/b12-9+/t18-,19+,21+/m1/s1
PubChem CID 6438394
MDL Number MFCD01632772
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A fungal metabolite with potent immunosuppressant activity that is 10-100 fold more compared to Cyclosporin A (Cat. No. 1522). It inhibits serine palmitoyltransferase (Ki = 0.28 nM) blocking the synthesis of ceramide. It was found to suppress melanoma cell proliferation by cell cycle arrest at the G 2/M phase through decreased sphingolipid levels and increased p53 and p21 (waf1/cip1) expression.

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