Product Details
| Antibody Target | MPO |
|---|---|
| Host | Rabbit |
| Antibody Type | Polyclonal |
| Isotype | Rabbit IgG |
| Immunogen | Synthetic peptide surrounding amino acid 765 of human MPO |
| Accession # | EAW94472.1 |
| Gene ID | 4353 |
| Appearance | Colorless liquid |
| Concentration | 0.5 mg/ml |
| Formulation | 100 µg (0.5 mg/ml) affinity purified rabbit anti-MPO polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal. |
| Purification | Affinity purified |
| Species Reactivity | Human, mouse |
| Application | Western blot |
| Application & Usage | Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes 60-100 kDa MPO from samples of human, mouse, and rat origins. Reactivity to other species has not been tested. |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20 °C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Myeloperoxidase (MPO) is highly expressed in neutrophils and polymorphonuclear luekocytes. MPO is expressed as a dimer in regular neutrophils with a 140kDA. The glycoslated form of MPO has a molecular weight of 92kDa and when undergoes a final glycoslyation, MPO forms subunits of 60kDa and 12kDa. In recent studies, MPO was shown to be involved in the initiation and progression of cardiovascular disease.
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