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mTOR Inhibitor, WYE-23

A sub-nanomolar potent mTOR inhibitor
Catalog #: 2257
SKU-Size Size Price Qty
2257-500 500 µg
$70.00
2257-1000 1 mg
$110.00
More Sizes Get Quote

Product Details

Alternate Name 4-{6-[4-(3-Cyclopropyl-ureido)-phenyl]-4-morpholin-4-yl-pyrazolo[3,4-d]pyrimidin-1-yl}-piperidine-1-carboxylic acid methyl ester
Appearance White solid
CAS # 1062169-46-3
Molecular Formula C₂₆H₃₂N₈O₄
Molecular Weight 520.58
Purity ≥98% by HPLC
Solubility DMSO (>10 mg/ml)
SMILES COC(=O)N1CCC(CC1)N2C3=C(C=N2)C(=NC(=N3)C4=CC=C(C=C4)NC(=O)NC5CC5)N6CCOCC6
InChi InChI=1S/C26H32N8O4/c1-37-26(36)33-10-8-20(9-11-33)34-24-21(16-27-34)23(32-12-14-38-15-13-32)30-22(31-24)17-2-4-18(5-3-17)28-25(35)29-19-6-7-19/h2-5,16,19-20H,6-15H2,1H3,(H2,28,29,35)
InChi Key NQNFBVOZVJAWSQ-UHFFFAOYSA-N
PubChem CID 44233391
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. A potent, selective, and ATP-competitive mTOR (mammalian Target Of Rapamycin) inhibitor (IC₅₀ = 0.45 nM nM). Displays 1469-fold selectivity over PI3Kα (IC₅₀ = 661 nM).


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